{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:53:00Z","timestamp":1788915180009,"version":"build-2803163510"},"reference-count":58,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6765","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2025,9,11]]},"abstract":"<jats:p>\n                    Carbon fixation through the Calvin-Benson-Bassham (CBB) cycle accounts for the majority of carbon dioxide (CO\n                    <jats:sub>2<\/jats:sub>\n                    ) uptake from the atmosphere. The CBB cycle generates C3 carbohydrates but is inefficient at producing acetyl\u2013coenzyme A (CoA) (C2), which is the universal precursor for synthesizing lipids. In this work, we introduced in\n                    <jats:italic toggle=\"yes\">Arabidopsis thaliana<\/jats:italic>\n                    a new-to-nature CO\n                    <jats:sub>2<\/jats:sub>\n                    fixing cycle, malyl-CoA-glycerate (McG) cycle, which together with the CBB cycle forms a dual-cycle CO\n                    <jats:sub>2<\/jats:sub>\n                    fixation system. This cycle can fix one additional carbon by phosphoenolpyruvate carboxylase and convert the photorespiration product, glycolate, to acetyl-CoA. Plants with the McG cycle show enhanced protein abundance in their photosystems and enhanced photosystem II efficiency. McG plants had doubled CO\n                    <jats:sub>2<\/jats:sub>\n                    fixation rates under atmospheric CO\n                    <jats:sub>2<\/jats:sub>\n                    , increased lipid production, pronounced growth enhancement, and tripled the seed yield.\n                  <\/jats:p>","DOI":"10.1126\/science.adp3528","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:00:56Z","timestamp":1757613656000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":28,"title":["Dual-cycle CO\n                    <sub>2<\/sub>\n                    fixation enhances growth and lipid synthesis in\n                    <i>Arabidopsis thaliana<\/i>"],"prefix":"10.1126","volume":"389","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5401-7500","authenticated-orcid":true,"given":"Kuan-Jen","family":"Lu","sequence":"first","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan."},{"name":"Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6691-3521","authenticated-orcid":true,"given":"Chia-Wei","family":"Hsu","sequence":"additional","affiliation":[{"name":"Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wann-Neng","family":"Jane","sequence":"additional","affiliation":[{"name":"Institute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9906-9048","authenticated-orcid":true,"given":"Mien-Hao","family":"Peng","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Wen","family":"Chou","sequence":"additional","affiliation":[{"name":"Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin-Hsuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3791-3423","authenticated-orcid":true,"given":"Kuo-Chen","family":"Yeh","sequence":"additional","affiliation":[{"name":"Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7179-3138","authenticated-orcid":true,"given":"Shu-Hsing","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4580-7276","authenticated-orcid":true,"given":"James C.","family":"Liao","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/pce.12425"},{"key":"e_1_3_2_3_2","first-page":"715","article-title":"Expression of cyanobacterial FBP\/SBPase in soybean prevents yield depression under future climate conditions","volume":"68","author":"K\u00f6hler I. 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