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We have systematically isolated and characterized gut fungi, identifying\n                    <jats:italic toggle=\"yes\">Fusarium foetens<\/jats:italic>\n                    as an intestinal symbiotic filamentous fungus in mice.\n                    <jats:italic toggle=\"yes\">F. foetens<\/jats:italic>\n                    reverses MASH progression in mouse models through an intestinal ceramide synthetase 6 (CerS6)\u2013ceramide axis. Moreover, we identified FF-C1, a secondary metabolite from\n                    <jats:italic toggle=\"yes\">F. foetens<\/jats:italic>\n                    , as a CerS6 inhibitor that has an endogenous protective effect on MASH progression.\n                  <\/jats:p>","DOI":"10.1126\/science.adp5540","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T16:26:53Z","timestamp":1747758413000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":52,"title":["A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite\u2013CerS6\u2013ceramide axis"],"prefix":"10.1126","volume":"388","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2338-7394","authenticated-orcid":true,"given":"Shuang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive 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