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Five distinct lesion microenvironments emerged, involving neuroglial responses, tissue destruction and repair, and brain border regulation. Before demyelination, MRI identified a high ratio of proton density\u2013weighted signal to\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    relaxation time, capturing early hypercellularity, and elevated astrocytic and ependymal senescence signals marked perivascular and periventricular areas that later became demyelination hotspots. As lesions expanded, concentric glial barriers formed, initially dominated by proliferating and diversifying microglia and oligodendrocyte precursors, later replaced by monocytes and lymphocytes. We highlight SERPINE1\n                    <jats:sup>+<\/jats:sup>\n                    astrocytes as a signaling hub underlying lesion onset in both marmoset EAE and MS.\n                  <\/jats:p>","DOI":"10.1126\/science.adp6325","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T14:01:26Z","timestamp":1740664886000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":29,"title":["4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis\u2013like lesions"],"prefix":"10.1126","volume":"387","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0686-0215","authenticated-orcid":true,"given":"Jing-Ping","family":"Lin","sequence":"first","affiliation":[{"name":"Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, 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