{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:00:46Z","timestamp":1789700446678,"version":"4.0.1"},"reference-count":63,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6774","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2025,11,13]]},"abstract":"<jats:p>\n                    Multiple sclerosis (MS) progresses through brain region\u2013specific inflammation and degeneration, with poorly defined mechanisms. In individuals with MS, we identified increased expression of formyl peptide receptor 1 (FPR1) in central nervous system (CNS)\u2013resident microglia and CNS-infiltrating macrophages. Blood amounts of\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    -formylated peptides, which are endogenous agonists of FPR1, correlated with disease progression in patients with MS. In MS mouse models, signaling through FPR1 promoted microglial mitochondrial dysfunction, causing axonal loss and apoptosis. FPR1-expressing microglia sustained the clonal expansion of myelin-reactive CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells in the CNS. A CNS-penetrating small molecule FPR1 antagonist, T0080, mitigated autoimmune responses and axonal degeneration. Our study identifies FPR1 signaling as a potential mechanism for MS progression and suggests antagonizing FPR1 as a therapeutic approach.\n                  <\/jats:p>","DOI":"10.1126\/science.adq1177","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T19:02:59Z","timestamp":1763060579000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":20,"title":["Targeting formyl peptide receptor 1 reduces brain inflammation and neurodegeneration"],"prefix":"10.1126","volume":"390","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5997-9775","authenticated-orcid":true,"given":"Yulin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China."},{"name":"Department of Neurology, Tiantan Neuroimaging Center of Excellence, China National Clinical Research Canter for Neurological Disease, Beijing Tiantan Hospital, Capital 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