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CXCR3 expression by CD8 T cells was required for their hours-long reengagement with DCs in specific subfollicular niches in lymph nodes. CD4 T cells paused briefly at the sites of CD8 T cell and DC interactions and provided Interleukin-2 (IL-2) before moving to another DC. Our results highlight a previously unappreciated phase of cell-cell interactions during T cell priming and have direct implications for vaccinations and cellular immunotherapies.<\/jats:p>","DOI":"10.1126\/science.adq1405","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T18:00:01Z","timestamp":1744308001000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":59,"title":["A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals"],"prefix":"10.1126","volume":"388","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2483-8062","authenticated-orcid":true,"given":"Katarzyna","family":"Jobin","sequence":"first","affiliation":[{"name":"W\u00fcrzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-University W\u00fcrzburg, W\u00fcrzburg, 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