{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:12:33Z","timestamp":1790856753101,"version":"4.1.0"},"reference-count":115,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6797","funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["31003A"],"award-info":[{"award-number":["31003A"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["172994"],"award-info":[{"award-number":["172994"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030"],"award-info":[{"award-number":["310030"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["200406"],"award-info":[{"award-number":["200406"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["170969"],"award-info":[{"award-number":["170969"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2026,4,30]]},"abstract":"<jats:p>\n                    The generation of effector CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells (T\n                    <jats:sub>EFF<\/jats:sub>\n                    ) requires activation of na\u00efve CCR7\n                    <jats:sup>+<\/jats:sup>\n                    T cells (T\n                    <jats:sub>N<\/jats:sub>\n                    ) by dendritic cells (DCs) in lymphoid tissue. How T\n                    <jats:sub>N<\/jats:sub>\n                    -DC interaction duration and signal integration are controlled remains unclear. In this study, we show that lymphoid stroma\u2013secreted CCR7 ligands limit interaction duration by progressively inducing CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell release from DCs. At late interaction stages, CCR7 ligands relocalize the F-actin regulator DOCK2 away from the DC interface, permitting T cell detachment, proliferation onset, and acquisition of cytotoxicity. Disruption of CCR7 signaling causes prolonged T cell\u2013DC contacts and produces dysfunctional T\n                    <jats:sub>EFF<\/jats:sub>\n                    with elevated inhibitory receptors, reduced antimicrobial activity, and impaired recall responses. Stromal chemokines therefore act as critical regulators of T cell priming by DCs, preserving CD8\n                    <jats:sup>+<\/jats:sup>\n                    effector function during acute and memory phases.\n                  <\/jats:p>","DOI":"10.1126\/science.adq2080","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:01:06Z","timestamp":1777572066000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Lymphoid tissue chemokines limit priming duration to preserve CD8\n                    <sup>+<\/sup>\n                    T cell functionality"],"prefix":"10.1126","volume":"392","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7998-5484","authenticated-orcid":true,"given":"Lukas M.","family":"Altenburger","sequence":"first","affiliation":[{"name":"Department of Oncology, Microbiology and Immunology, University of Fribourg, Fribourg, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2348-3378","authenticated-orcid":true,"given":"Daniela Claudino","family":"Carvoeiro","sequence":"additional","affiliation":[{"name":"Department of Oncology, Microbiology and Immunology, University of Fribourg, Fribourg, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9869-2601","authenticated-orcid":true,"given":"Philippe","family":"Dehio","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, University of Basel, Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6729-1154","authenticated-orcid":true,"given":"Jianwen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Fribourg, Fribourg, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3949-2538","authenticated-orcid":true,"given":"Chiara","family":"Laura","sequence":"additional","affiliation":[{"name":"Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1905-0430","authenticated-orcid":true,"given":"\u00c0lex","family":"Bofi i Cuadros","sequence":"additional","affiliation":[{"name":"Department of Oncology, Microbiology and Immunology, University of Fribourg, Fribourg, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9248-6348","authenticated-orcid":true,"given":"Mitali","family":"Katoch","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg (FAU), Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7340-3861","authenticated-orcid":true,"given":"Juliana Barreto","family":"de Albuquerque","sequence":"additional","affiliation":[{"name":"Department of Oncology, Microbiology and Immunology, University of Fribourg, Fribourg, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1152-5278","authenticated-orcid":true,"given":"Petra","family":"Pfenninger","sequence":"additional","affiliation":[{"name":"Department of Oncology, Microbiology and Immunology, University of Fribourg, Fribourg, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6366-5892","authenticated-orcid":true,"given":"Jose Mart\u00ednez","family":"Magdaleno","sequence":"additional","affiliation":[{"name":"Department of Oncology, Microbiology and Immunology, University of Fribourg, Fribourg, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8599-1226","authenticated-orcid":true,"given":"Matthias","family":"Mehling","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, University of Basel, Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9370-2671","authenticated-orcid":true,"given":"Matteo","family":"Iannacone","sequence":"additional","affiliation":[{"name":"Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy."},{"name":"Vita-Salute San Raffaele University, Milan, Italy."},{"name":"Experimental Imaging Center, IRCCS San Raffaele Scientific Institute, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Hashemi","family":"Gheinani","sequence":"additional","affiliation":[{"name":"Functional Urology Research Group, Department for BioMedical Research DBMR, University of Bern, Bern, Switzerland."},{"name":"Department of Urology, Inselspital University Hospital, Bern, Switzerland."},{"name":"Urological Diseases Research Center, Boston Children\u2019s Hospital, Boston, MA, USA."},{"name":"Harvard Medical School, Department of Surgery, Boston, MA, USA."},{"name":"Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9453-4614","authenticated-orcid":true,"given":"J\u00f6rn","family":"Dengjel","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Fribourg, Fribourg, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7511-4502","authenticated-orcid":true,"given":"Jun","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Oncology, Microbiology and Immunology, University of Fribourg, Fribourg, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8199-9586","authenticated-orcid":true,"given":"Jens V.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Oncology, Microbiology and Immunology, University of Fribourg, Fribourg, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175455"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3905"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2297"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1513"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abb9435"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00540-z"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.10.011"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300739"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002515"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260044"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1413726111"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/87730"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/87720"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni912"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.10.5165"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060928"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008555"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.ade3369"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1131078"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1790"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.11.017"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110308"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90169-4"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160206"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02238"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171708"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07657"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.2MR0815-380R"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04651"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120145"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070051"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2007.06.005"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.129923.1"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2889"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050783"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160620"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061706"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.5.2973"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601148"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1144830"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1605"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1190"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3492"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.11.031"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.06.005"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1071065"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041236"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1039803"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80409-4"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062079"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.27827"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.03.025"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.02.010"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/35090591"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00169-9"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131324"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-200923"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0109-z"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200602142"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061780"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2010.02.004"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa4967"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0979-8"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-022-00942-8"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113898"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2012.03.008"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2025.108423"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.07.021"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00563-6"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01194-2"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00884-8"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05105-1"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abe3702"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070322"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.05.009"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1901512"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235454"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235487"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201730"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.12.006"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1326-9"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1325-x"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0403-4"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.06.015"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0760-z"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01578-y"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001983"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0221-9"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a037929"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2021.05.004"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00285"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402520"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-17-0405"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01303"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901089"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.2001.1895"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2467"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<110::AID-GENE2>3.0.CO;2-8"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80059-8"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15327"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abf1861"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.24501"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2016.08.004"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0198330"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz114"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-3-r25"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2014-15-2-r29"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M114.044305"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3901"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.037309"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.031"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20150598"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah6499"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1106"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.adq2080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:01:49Z","timestamp":1777572109000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.adq2080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":115,"journal-issue":{"issue":"6797","published-print":{"date-parts":[[2026,4,30]]}},"alternative-id":["10.1126\/science.adq2080"],"URL":"https:\/\/doi.org\/10.1126\/science.adq2080","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]},"assertion":[{"value":"2024-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-25","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadq2080"}}