{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:58:56Z","timestamp":1792198736477,"version":"4.4.0"},"reference-count":48,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6742","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2025,4,4]]},"abstract":"<jats:p>\n                    T cells have emerged as orchestrators of pain amplification, but the mechanism by which T cells control pain processing is unresolved. We found that regulatory T cells (T\n                    <jats:sub>reg<\/jats:sub>\n                    cells) could inhibit nociception through a mechanism that was not dependent on their ability to regulate immune activation and tissue repair. Site-specific depletion or expansion of meningeal T\n                    <jats:sub>reg<\/jats:sub>\n                    cells (mT\n                    <jats:sub>reg<\/jats:sub>\n                    cells) in mice led to female-specific and sex hormone\u2013dependent modulation of mechanical sensitivity. Specifically, mT\n                    <jats:sub>reg<\/jats:sub>\n                    cells produced the endogenous opioid enkephalin that exerted an antinociceptive action through the delta opioid receptor expressed by MrgprD\n                    <jats:sup>+<\/jats:sup>\n                    sensory neurons. Although enkephalin restrains nociceptive processing, it was dispensable for T\n                    <jats:sub>reg<\/jats:sub>\n                    cell\u2013mediated immunosuppression. Thus, our findings uncovered a sexually dimorphic immunological circuit that restrains nociception, establishing T\n                    <jats:sub>reg<\/jats:sub>\n                    cells as sentinels of pain homeostasis.\n                  <\/jats:p>","DOI":"10.1126\/science.adq6531","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:30:56Z","timestamp":1743726656000},"page":"96-104","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":49,"title":["Meningeal regulatory T cells inhibit nociception in female mice"],"prefix":"10.1126","volume":"388","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-8975","authenticated-orcid":true,"given":"\u00c9lora","family":"Midavaine","sequence":"first","affiliation":[{"name":"Department of Anatomy, University of California San Francisco, San Francisco, CA, 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