{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:42:20Z","timestamp":1791495740474,"version":"4.3.4"},"reference-count":97,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6729","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2025,1,3]]},"abstract":"<jats:p>\n            The most advanced monoclonal antibodies (mAbs) and vaccines against malaria target the central repeat region or closely related sequences within the\n            <jats:italic>Plasmodium falciparum<\/jats:italic>\n            circumsporozoite protein (PfCSP). Here, using an antigen-agnostic strategy to investigate human antibody responses to whole sporozoites, we identified a class of mAbs that target a cryptic PfCSP epitope that is only exposed after cleavage and subsequent pyroglutamylation (pGlu) of the newly formed N terminus. This pGlu-CSP epitope is not targeted by current anti-PfCSP mAbs and is not included in the licensed malaria vaccines. MAD21-101, the most potent mAb in this class, confers sterile protection against\n            <jats:italic>Pf<\/jats:italic>\n            infection in a human liver\u2013chimeric mouse model. These findings reveal a site of vulnerability on the sporozoite surface that can be targeted by next-generation antimalarial interventions.\n          <\/jats:p>","DOI":"10.1126\/science.adr0510","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T18:59:17Z","timestamp":1735844357000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":24,"title":["Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein"],"prefix":"10.1126","volume":"387","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-2740","authenticated-orcid":true,"given":"Cherrelle","family":"Dacon","sequence":"first","affiliation":[{"name":"Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6091-1285","authenticated-orcid":true,"given":"Re\u2019em","family":"Moskovitz","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6756-4471","authenticated-orcid":true,"given":"Kristian","family":"Swearingen","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lais","family":"Da Silva Pereira","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7230-3834","authenticated-orcid":true,"given":"Yevel","family":"Flores-Garcia","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology and Johns Hopkins Malaria Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5471-4242","authenticated-orcid":true,"given":"Maya","family":"Aleshnick","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute, Oregon Health &amp; Science University, Portland, OR, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7072-0447","authenticated-orcid":true,"given":"Sachie","family":"Kanatani","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology and Johns Hopkins Malaria Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Flynn","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5137-4836","authenticated-orcid":true,"given":"Alvaro","family":"Molina-Cruz","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4973-9370","authenticated-orcid":true,"given":"Kurt","family":"Wollenberg","sequence":"additional","affiliation":[{"name":"Bioinformatics &amp; Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8267-4161","authenticated-orcid":true,"given":"Maria","family":"Traver","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payton","family":"Kirtley","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute, Oregon Health &amp; Science University, Portland, OR, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Purser","sequence":"additional","affiliation":[{"name":"Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-5487","authenticated-orcid":true,"given":"Marlon","family":"Dillon","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4067-7476","authenticated-orcid":true,"given":"Brian","family":"Bonilla","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Franco","sequence":"additional","affiliation":[{"name":"Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Petros","sequence":"additional","affiliation":[{"name":"Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3962-0237","authenticated-orcid":true,"given":"Jake","family":"Kritzberg","sequence":"additional","affiliation":[{"name":"Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8632-8952","authenticated-orcid":true,"given":"Courtney","family":"Tucker","sequence":"additional","affiliation":[{"name":"Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA."},{"name":"Department of Biology, The Catholic University of America, Washington, DC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4708-5753","authenticated-orcid":true,"given":"Gonzalo Gonzalez","family":"Paez","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Gupta","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8226-4354","authenticated-orcid":true,"given":"Melanie J.","family":"Shears","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Pazzi","sequence":"additional","affiliation":[{"name":"Antigen Discovery, Incorporated, Irvine, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4905-3776","authenticated-orcid":true,"given":"Joshua M.","family":"Edgar","sequence":"additional","affiliation":[{"name":"Antigen Discovery, Incorporated, Irvine, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2088-2181","authenticated-orcid":true,"given":"Andy A.","family":"Teng","sequence":"additional","affiliation":[{"name":"Antigen Discovery, Incorporated, Irvine, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1738-6240","authenticated-orcid":true,"given":"Arnel","family":"Belmonte","sequence":"additional","affiliation":[{"name":"General Dynamics Information Technology, Inc., Falls Church, VA, USA."},{"name":"Agile Vaccines and Therapeutics Department, Naval Medical Research Command, Silver Spring, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5186-6993","authenticated-orcid":true,"given":"Kyosuke","family":"Oda","sequence":"additional","affiliation":[{"name":"Agile Vaccines and Therapeutics Department, Naval Medical Research Command, Silver Spring, MD, USA."},{"name":"Henry M Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0974-0860","authenticated-orcid":true,"given":"Safiatou","family":"Doumbo","sequence":"additional","affiliation":[{"name":"Mali International Center of Excellence in Research, University of Sciences, Technique and Technology of Bamako, Bamako, Mali."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Krymskaya","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5697-0442","authenticated-orcid":true,"given":"Jeff","family":"Skinner","sequence":"additional","affiliation":[{"name":"Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0998-2082","authenticated-orcid":true,"given":"Shanping","family":"Li","sequence":"additional","affiliation":[{"name":"Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Ghosal","sequence":"additional","affiliation":[{"name":"Bioinformatics &amp; Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6877-0093","authenticated-orcid":true,"given":"Kassoum","family":"Kayentao","sequence":"additional","affiliation":[{"name":"Mali International Center of Excellence in Research, University of Sciences, Technique and Technology of Bamako, Bamako, Mali."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8797-497X","authenticated-orcid":true,"given":"Aissata","family":"Ongoiba","sequence":"additional","affiliation":[{"name":"Mali International Center of Excellence in Research, University of Sciences, Technique and Technology of Bamako, Bamako, Mali."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5815-756X","authenticated-orcid":true,"given":"Ashley","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8652-0917","authenticated-orcid":true,"given":"Joseph J.","family":"Campo","sequence":"additional","affiliation":[{"name":"Antigen Discovery, Incorporated, Irvine, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boubacar","family":"Traore","sequence":"additional","affiliation":[{"name":"Mali International Center of Excellence in Research, University of Sciences, Technique and Technology of Bamako, Bamako, Mali."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4039-6199","authenticated-orcid":true,"given":"Carolina","family":"Barillas-Mury","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wathsala","family":"Wijayalath","sequence":"additional","affiliation":[{"name":"Agile Vaccines and Therapeutics Department, Naval Medical Research Command, Silver Spring, MD, USA."},{"name":"Henry M Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1847-5488","authenticated-orcid":true,"given":"Azza","family":"Idris","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA."},{"name":"The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5629-0412","authenticated-orcid":true,"given":"Peter D.","family":"Crompton","sequence":"additional","affiliation":[{"name":"Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2954-7547","authenticated-orcid":true,"given":"Photini","family":"Sinnis","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology and Johns Hopkins Malaria Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5577-7787","authenticated-orcid":true,"given":"Brandon K.","family":"Wilder","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute, Oregon Health &amp; Science University, Portland, OR, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1414-6196","authenticated-orcid":true,"given":"Fidel","family":"Zavala","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology and Johns Hopkins Malaria Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3133-0849","authenticated-orcid":true,"given":"Robert A.","family":"Seder","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6469-2419","authenticated-orcid":true,"given":"Ian A.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA."},{"name":"The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6661-6372","authenticated-orcid":true,"given":"Joshua","family":"Tan","sequence":"additional","affiliation":[{"name":"Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization \u201cWorld malaria report 2023\u201d (WHO 2023); https:\/\/www.who.int\/teams\/global-malaria-programme\/reports\/world-malaria-report-2023."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1997.57.426"},{"key":"e_1_3_2_4_2","first-page":"27","article-title":"The demonstration of sporozoites in human tissues","volume":"19","author":"Boyd M. F.","year":"1938","unstructured":"M. F. Boyd, S. F. Kitchen, The demonstration of sporozoites in human tissues. Am. J. Trop. Med. Hyg. 19, 27\u201331 (1938).","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1350"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2004.05.005"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.07789"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.291.5501.141"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025478"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1529"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000399"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00600-07"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-44962-4"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4513"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4512"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0881-9"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.08.014"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.157.6.1947"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6985745"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6204383"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60721-8"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00442-X"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02511-4"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206966"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312775"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02659-z"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005606"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw849"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit174"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241800"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4110"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-019-3055-9"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040989"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2209729119"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.11.3628"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M112.024505"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715812114"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv154"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21221-4"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40151-x"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-84622-x"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113330"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.18681.1"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-020-03315-4"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043430"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-022-04275-7"},{"key":"e_1_3_2_47_2","unstructured":"World Health Organization \u201cMonoclonal antibodies for malaria prevention: Preferred product characteristics and clinical development considerations\u201d (WHO 2023); https:\/\/www.who.int\/publications\/i\/item\/9789240070981."},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01249-13"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01924-3"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101488"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.156.1.20"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007860"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.07.001"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.06.037"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.06.015"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfimm\/iqab015"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112681"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02194-18"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.3791\/61426-v"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M705873200"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-11-421"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.117"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.10.7972-7980.1999"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abj5413"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2007.09.017"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00022"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.011268"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01108-12"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.53080"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00418-22"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-394"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232311"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(97)76066-X"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889807021206"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw361"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444911001314"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444912001308"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444904019158"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1040"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1038"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01184-6"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2377"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13361-015-1179-x"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.2c00624"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01097"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.15194.1"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn814"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad1003"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-021-00963-z"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cois.2021.11.008"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(93)87010-3"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giab008"},{"key":"e_1_3_2_93_2","unstructured":"R Core Team \u201cR: A language and environment for statistical computing\u201d (R Foundation for Statistical Computing 2024); www.R-project.org\/."},{"key":"e_1_3_2_94_2","unstructured":"M. Krassowski \u201ckrassowski\/complex-upset: v1.3.5\u201d (Zenodo 2020); https:\/\/doi.org\/10.5281\/zenodo.3700590"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1109\/TVCG.2014.2346248"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-017-0028-2"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.19-0094"},{"key":"e_1_3_2_98_2","unstructured":"C. Dacon R. Moskovitz K. Swearingen L. Da Silva Pereira Y. Flores-Garcia M. Aleshnick S. Kanatani B. Flynn A. Molina-Cruz K. Wollenberg M. Traver P. Kirtley L. Purser M. Dillon B. Bonilla A. Franco S. Petros J. Kritzberg C. Tucker G. Gonzalez Paez P. Gupta M. J. Shears J. Pazzi J. M. Edgar A. A. Teng A. Belmonte K. Oda S. Doumbo L. Krymskaya J. Skinner S. Li S. Ghosal K. Kayentao A. Ongoiba A. Vaughan J. J. Campo B. Traore C. Barillas-Mury W. Wijayalath A. Idris P. D. Crompton P. Sinnis B. K. Wilder F. Zavala R. A. Seder I. A. Wilson J. Tan Data for: Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein Dryad (2024); https:\/\/doi.org\/10.5061\/dryad.fttdz0930"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.adr0510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T18:59:32Z","timestamp":1735844372000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.adr0510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,3]]},"references-count":97,"journal-issue":{"issue":"6729","published-print":{"date-parts":[[2025,1,3]]}},"alternative-id":["10.1126\/science.adr0510"],"URL":"https:\/\/doi.org\/10.1126\/science.adr0510","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,3]]},"assertion":[{"value":"2024-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadr0510"}}