{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T07:05:55Z","timestamp":1793430355204,"version":"4.5.0"},"reference-count":38,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6779","funder":[{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007674","name":"Institute of Molecular and Cell Biology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007674","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Medical Research Council Open Fund-Individual Research Grant","award":["OFIRG19may-0069"],"award-info":[{"award-number":["OFIRG19may-0069"]}]},{"name":"National Medical Research Council Open Fund-Young Individual Research Grant","award":["OFYIRG22jul-0006"],"award-info":[{"award-number":["OFYIRG22jul-0006"]}]},{"name":"Target Translation Consortium Grant","award":["TTC2019-002"],"award-info":[{"award-number":["TTC2019-002"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2025,12,18]]},"abstract":"<jats:p>\n                    Cancer stem cells (CSCs) represent a self-renewing population capable of fueling long-term tumor growth. In gastric cancer, the identity of CSC populations remains unclear. In this study, we established a gastric CSC population marked by the water channel protein aquaporin-5 (AQP5), which resides in human and mouse pyloric tumors. Using multiple organoid and mouse models, we found a requirement for AQP5\n                    <jats:sup>+<\/jats:sup>\n                    CSCs in both initiating and sustaining cancer progression and demonstrated that AQP5 expression also directly promotes tumor growth and invasion in a WNT, PI3K (phosphatidylinositol 3-kinase), and MAPK (mitogen-activated protein kinase)\u2013dependent manner. Beyond primary cancers, AQP5 further enriches for a functional CSC population in metastatic tumors. Together, our findings support a CSC model in gastric tumors that may have application for therapeutic strategies targeting CSCs.\n                  <\/jats:p>","DOI":"10.1126\/science.adr2428","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:02:29Z","timestamp":1766084549000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":8,"title":["AQP5: A functional gastric cancer stem cell marker in mouse and human tumors"],"prefix":"10.1126","volume":"390","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3241-9952","authenticated-orcid":true,"given":"Hui Yi Grace","family":"Lim","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore, Republic of 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