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Timing and complexity of microbial perturbations and type 2 inflammation result in motor neuron state shifts and alter multiple functionally distinct sensory neurons, including interleukin-13\u2013 and leukotriene-responsive\n                    <jats:italic toggle=\"yes\">Nmu<\/jats:italic>\n                    -hi cells and\n                    <jats:italic toggle=\"yes\">Grp<\/jats:italic>\n                    -hi neurons, which expand in germ-free colonic tissue and interact with\n                    <jats:italic toggle=\"yes\">Grpr<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    interstitial cells of Cajal. Leveraging adeno-associated virus\u2013based Perturb-seq, we identified\n                    <jats:italic toggle=\"yes\">Edf1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Mitf<\/jats:italic>\n                    as controllers of motor neuron state transition and gastrointestinal transit time, directly linking enteric neuron states to physiology.\n                  <\/jats:p>","DOI":"10.1126\/science.adr3545","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:01:37Z","timestamp":1761847297000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":17,"title":["Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation"],"prefix":"10.1126","volume":"390","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6992-9000","authenticated-orcid":true,"given":"Peng","family":"Tan","sequence":"first","affiliation":[{"name":"Klarman 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