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In obese mice lacking the endothelial adrenomedullin receptor, insulin-induced endothelial nitric oxide\u2013synthase activation and skeletal muscle perfusion were increased. Treating mice with adrenomedullin mimicked the effect of obesity and induced endothelial and systemic insulin resistance. Endothelial loss or blockade of the adrenomedullin receptor improved obesity-induced insulin resistance. These findings identify a mechanism underlying obesity-induced systemic insulin resistance and suggest approaches to treat obesity-associated type 2 diabetes.<\/jats:p>","DOI":"10.1126\/science.adr4731","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T18:59:31Z","timestamp":1738868371000},"page":"674-682","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":70,"title":["Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes"],"prefix":"10.1126","volume":"387","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6577-5320","authenticated-orcid":true,"given":"Haaglim","family":"Cho","sequence":"first","affiliation":[{"name":"Max Planck Institute for Heart and Lung Research, Department of Pharmacology, Bad Nauheim, 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