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During infection of cultured mammalian cells with the intracellular pathogen\n            <jats:italic toggle=\"yes\">Toxoplasma gondii<\/jats:italic>\n            , ATF4 increased mitochondrial DNA levels by driving the one-carbon metabolism processes that use folate in mitochondria. Triggered by host detection of mitochondrial stress induced by parasite effectors, ATF4 limited\n            <jats:italic toggle=\"yes\">Toxoplasma<\/jats:italic>\n            access to folates required for deoxythymidine monophosphate synthesis, thereby restricting parasite growth. Thus, ATF4 rewires mitochondrial metabolism to mount a folate-based metabolic defense against\n            <jats:italic toggle=\"yes\">Toxoplasma<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1126\/science.adr6326","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T18:00:41Z","timestamp":1755194441000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":25,"title":["Mitochondria protect against an intracellular pathogen by restricting access to folate"],"prefix":"10.1126","volume":"389","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5843-3763","authenticated-orcid":true,"given":"T\u00e2nia Catarina","family":"Medeiros","sequence":"first","affiliation":[{"name":"Metabolism of Infection Group, Max Planck Institute for Biology of Ageing, Cologne, 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