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Imaging and machine learning\u2013based analysis validated in situ DNTs as anatomically distinct from synaptic spines. DNTs actively transported small molecules and human amyloid-\u03b2 (A\u03b2); DNT density increased before plaque formation in the medial prefrontal cortex of APP\/PS1 mice (APP, A\u03b2 precursor protein; PS1, presenilin-1), suggesting that the dendrite-DNT network might play a role in Alzheimer\u2019s disease pathology. Computational models of DNT-mediated A\u03b2 propagation recapitulated early amyloidosis, predicting selective intracellular accumulation. These findings uncover a nanotubular connectivity layer in the brain, extending neuronal communication beyond classical synapses.\n          <\/jats:p>","DOI":"10.1126\/science.adr7403","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T18:00:35Z","timestamp":1759428035000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":36,"title":["Intercellular communication in the brain through a dendritic nanotubular network"],"prefix":"10.1126","volume":"390","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3785-4400","authenticated-orcid":true,"given":"Minhyeok","family":"Chang","sequence":"first","affiliation":[{"name":"The Solomon H. 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