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The transformation is prenyl conjugate addition to cyclic \u03b2-ketoesters promoted by a readily accessible chiral copper catalyst and involving an easy-to-prepare and isolable organoborate reagent. Reactions reach completion in just a few minutes at room temperature. The importance of this advance is highlighted by the enantioselective preparation of intermediates previously used to generate racemic PPAPs. We also present the enantioselective synthesis of nemorosonol (14 steps, 20% yield) and its one-step conversion to another PPAP, garcibracteatone (52% yield).<\/jats:p>","DOI":"10.1126\/science.adr8612","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T17:59:30Z","timestamp":1728583170000},"page":"167-175","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":19,"title":["Catalytic prenyl conjugate additions for synthesis of enantiomerically enriched PPAPs"],"prefix":"10.1126","volume":"386","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9679-4057","authenticated-orcid":true,"given":"Shawn","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467, 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