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We report that transcription factor Etv3 is preferentially expressed in mature DCs, including tissue-derived migratory DCs (migDCs), and facilitates their homeostatic maturation and CCR7-dependent migration. Mice with global or DC-specific deletion of Etv3 manifested the expansion of CD25\n                    <jats:sup>low<\/jats:sup>\n                    regulatory T (T\n                    <jats:sub>reg<\/jats:sub>\n                    ) cells, spontaneous activation of conventional T cells, and multiorgan T cell infiltration. Etv3 deficiency exacerbated TLR7-driven systemic lupus erythematosus (SLE)\u2013like disease, supporting the reported genetic association of human\n                    <jats:italic toggle=\"yes\">ETV3<\/jats:italic>\n                    with SLE. Etv3-deficient migDCs up-regulated multiple costimulatory molecules, including OX40 ligand (OX40L\/TNFSF4), whose blockade partially rescued the T\n                    <jats:sub>reg<\/jats:sub>\n                    cell abnormalities. 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