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Among these NSGs,\n                    <jats:italic toggle=\"yes\">growth arrest and DNA damage\u2013inducible protein 34<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">GADD34<\/jats:italic>\n                    ) was crucial for IAV restriction. Some IAVs have evolved to evade activating human STING by mutating residue 115 in their matrix protein 1 (M1), which is essential for efficient viral replication in human respiratory cells. This barrier against the zoonotic threat of IAVs provides a tool for future investigations into the biological functions of the cyclic guanosine monophosphate\u2013adenosine monosphosphate (cGMP-AMP) synthase (cGAS)\u2013STING\u2013NF-\u03baB signaling pathway.\n                  <\/jats:p>","DOI":"10.1126\/science.ads4405","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T19:01:33Z","timestamp":1772132493000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":4,"title":["STING\u2013NF-\u03baB signaling builds an influenza spillover barrier"],"prefix":"10.1126","volume":"391","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5093-9171","authenticated-orcid":true,"given":"Runxin","family":"Ye","sequence":"first","affiliation":[{"name":"Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, School of 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