{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:45:06Z","timestamp":1791996306746,"version":"4.4.0"},"reference-count":61,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6732","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2025,1,24]]},"abstract":"<jats:p>\n                    The mammalian Y chromosome is essential for male fertility, but which Y genes regulate spermatogenesis is unresolved. We addressed this by generating 13 Y-deletant mouse models. In\n                    <jats:italic>Eif2s3y<\/jats:italic>\n                    ,\n                    <jats:italic>Uty<\/jats:italic>\n                    , and\n                    <jats:italic>Zfy2<\/jats:italic>\n                    deletants, spermatogenesis was impaired. We found that\n                    <jats:italic>Uty<\/jats:italic>\n                    regulates spermatogonial proliferation, revealed a role for\n                    <jats:italic>Zfy2<\/jats:italic>\n                    in promoting meiotic sex chromosome pairing, and uncovered unexpected effects of Y genes on the somatic testis transcriptome. In the remaining single Y-gene deletants, spermatogenesis appeared unperturbed, but testis transcription was still altered. Multigene deletions, including a human-infertility AZFa model, exhibited phenotypes absent in single Y deletants. Thus, Y genes may regulate spermatogenesis even if they show no phenotypes when deleted individually. This study advances our knowledge of Y evolution and infertility and provides a resource to dissect Y-gene functions in other tissues.\n                  <\/jats:p>","DOI":"10.1126\/science.ads6495","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T13:59:23Z","timestamp":1737640763000},"page":"393-400","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":15,"title":["Systematic identification of Y-chromosome gene functions in mouse spermatogenesis"],"prefix":"10.1126","volume":"387","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5633-0509","authenticated-orcid":true,"given":"Jeremie","family":"Subrini","sequence":"first","affiliation":[{"name":"Sex Chromosome Biology Laboratory, The Francis Crick Institute, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4988-4551","authenticated-orcid":true,"given":"Wazeer","family":"Varsally","sequence":"additional","affiliation":[{"name":"Sex Chromosome Biology Laboratory, The Francis Crick Institute, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6636-7144","authenticated-orcid":true,"given":"Irina Balaguer","family":"Balsells","sequence":"additional","affiliation":[{"name":"Sex Chromosome Biology Laboratory, The Francis Crick Institute, London, UK."},{"name":"Developmental Epigenomics Group, MRC London Institute of Medical Sciences, Du Cane Road, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2395-6083","authenticated-orcid":true,"given":"Maike","family":"Bensberg","sequence":"additional","affiliation":[{"name":"Sex Chromosome Biology Laboratory, The Francis Crick Institute, London, UK."},{"name":"Crown Princess Victoria Children\u00b4s Hospital, and Department of Biomedical and Clinical Sciences (BKV), Link\u00f6ping University, Link\u00f6ping, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4804-2109","authenticated-orcid":true,"given":"Georgios","family":"Sioutas","sequence":"additional","affiliation":[{"name":"Sex Chromosome Biology Laboratory, The Francis Crick Institute, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obah","family":"Ojarikre","sequence":"additional","affiliation":[{"name":"Sex Chromosome Biology Laboratory, The Francis Crick Institute, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9627-7163","authenticated-orcid":true,"given":"Valdone","family":"Maciulyte","sequence":"additional","affiliation":[{"name":"Sex Chromosome Biology Laboratory, The Francis Crick Institute, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5253-6737","authenticated-orcid":true,"given":"Bj\u00f6rn","family":"Gylemo","sequence":"additional","affiliation":[{"name":"Sex Chromosome Biology Laboratory, The Francis Crick Institute, London, UK."},{"name":"Crown Princess Victoria Children\u00b4s Hospital, and Department of Biomedical and Clinical Sciences (BKV), Link\u00f6ping University, Link\u00f6ping, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3731-4786","authenticated-orcid":true,"given":"Katharine","family":"Crawley","sequence":"additional","affiliation":[{"name":"Genetic Modification Service (GeMS), The Francis Crick Institute, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2730-3349","authenticated-orcid":true,"given":"Katherine","family":"Courtis","sequence":"additional","affiliation":[{"name":"Genetic Modification Service (GeMS), The Francis Crick Institute, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3932-4419","authenticated-orcid":true,"given":"Dirk G.","family":"de Rooij","sequence":"additional","affiliation":[{"name":"Reproductive Biology Group, Division of Developmental Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands."},{"name":"Centre for Reproductive Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1722-7677","authenticated-orcid":true,"given":"James M. 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