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In embryos lacking\n                    <jats:italic toggle=\"yes\">Sp5<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Sp8<\/jats:italic>\n                    , primary and motile cilia were shorter than normal and reduced in number across cell types, contributing to situs inversus and hydrocephalus. Moreover, expression of SP8 was sufficient to induce primary cilia in unciliated cells. This work will facilitate the study of cilia assembly using stem cell models and promote further understanding of human ciliopathies.\n                  <\/jats:p>","DOI":"10.1126\/science.adt5663","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T18:00:57Z","timestamp":1756404057000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":11,"title":["Transcription factors SP5 and SP8 drive primary cilia formation in mammalian embryos"],"prefix":"10.1126","volume":"389","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9945-3768","authenticated-orcid":true,"given":"Yinwen","family":"Liang","sequence":"first","affiliation":[{"name":"Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 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