{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:29:02Z","timestamp":1787016542360,"version":"build-2736575974"},"reference-count":156,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6766","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2025,9,18]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Anopheles funestus<\/jats:italic>\n                    s.s. is a major human malaria vector across Africa. To study its evolution, especially under vector control pressure, we sequenced 656 modern specimens (collected 2014 to 2018) and 45 historic specimens (collected 1927 to 1967) from 16 African countries. Despite high genetic diversity, the species shows stable but considerable continental population structure. Although one population showed little differentiation over a century and 4000 kilometers, nearby, we found two genetically distinct ecotypes. Vector control has resulted in strong signals of selection, with some resistance alleles shared across populations through gene flow and others arising independently. Fortunately, we found that a promising gene drive target in\n                    <jats:italic toggle=\"yes\">Anopheles gambiae<\/jats:italic>\n                    is highly conserved in\n                    <jats:italic toggle=\"yes\">An. funestus<\/jats:italic>\n                    . These insights will enable more strategic insecticide usage and gene drive deployment, supporting malaria elimination.\n                  <\/jats:p>","DOI":"10.1126\/science.adu3596","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T18:00:32Z","timestamp":1758218432000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":14,"title":["Genomic diversity of the African malaria vector\n                    <i>Anopheles funestus<\/i>"],"prefix":"10.1126","volume":"389","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2107-5100","authenticated-orcid":true,"given":"Marilou","family":"Bodd\u00e9","sequence":"first","affiliation":[{"name":"Wellcome Sanger Institute, Hinxton, UK."},{"name":"Institut Pasteur de Madagascar, Antananarivo, Madagascar."},{"name":"Leibniz Institute for the Analysis of Biodiversity Change, Bonn, 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