{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:44:53Z","timestamp":1792521893707,"version":"4.5.0"},"reference-count":110,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6764","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2025,9,4]]},"abstract":"<jats:p>\n                    Evidence links air pollution to dementia, yet its role in Lewy body dementia (LBD) remains unclear. In this work, we showed in a cohort of 56.5 million individuals across the United States that fine particulate matter (PM\n                    <jats:sub>2.5<\/jats:sub>\n                    ) exposure raises LBD risk. Mechanistically, we found that PM\n                    <jats:sub>2.5<\/jats:sub>\n                    exposure led to brain atrophy in wild-type mice, an effect not seen in \u03b1-synuclein (\u03b1Syn)\u2013deficient mice. PM\n                    <jats:sub>2.5<\/jats:sub>\n                    exposure generated a highly pathogenic \u03b1Syn strain, PM\n                    <jats:sub>2.5<\/jats:sub>\n                    \u2013induced preformed fibril (PM-PFF), with enhanced proteinase K resistance and neurotoxicity, resembling \u03b1Syn LBD strains. PM\n                    <jats:sub>2.5<\/jats:sub>\n                    samples from China, the United States, and Europe consistently induced proteinase-resistant \u03b1Syn strains and in vivo pathology. Transcriptomic analyses revealed shared responses between PM\n                    <jats:sub>2.5<\/jats:sub>\n                    -exposed mice and LBD patients, underscoring PM\n                    <jats:sub>2.5<\/jats:sub>\n                    \u2019s role in LBD and stressing the need for interventions to reduce air pollution and its associated neurological disease burden.\n                  <\/jats:p>","DOI":"10.1126\/science.adu4132","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T18:01:48Z","timestamp":1757008908000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":44,"title":["Lewy body dementia promotion by air pollutants"],"prefix":"10.1126","volume":"389","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5452-4027","authenticated-orcid":true,"given":"Xiaodi","family":"Zhang","sequence":"first","affiliation":[{"name":"Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA."},{"name":"Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA."},{"name":"Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5721-0728","authenticated-orcid":true,"given":"Haiqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA."},{"name":"Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4884-657X","authenticated-orcid":true,"given":"Xiao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Columbia University Mailman School of 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