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We developed a biomimetic coupling between neuromuscular signaling and joint movement that exceeds the versatility of established control methods, which depend upon conventional amputation musculature and surface electromyography. Our findings also reveal that superior residual neuromuscular function can enable prosthetic movement speeds surpassing that of intact physiology. Anatomical prosthetic integration may be necessary for meeting, and possibly exceeding, the movement capabilities of an intact limb.<\/jats:p>","DOI":"10.1126\/science.adv3223","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T18:00:36Z","timestamp":1752170436000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":21,"title":["Tissue-integrated bionic knee restores versatile legged movement after amputation"],"prefix":"10.1126","volume":"389","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7495-7233","authenticated-orcid":true,"given":"Tony","family":"Shu","sequence":"first","affiliation":[{"name":"Program in Media Arts and Sciences, MIT Media Lab, MIT, Cambridge, MA, USA."},{"name":"K. 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