{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:18:19Z","timestamp":1790914699177,"version":"4.1.0"},"reference-count":81,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6809","license":[{"start":{"date-parts":[[2027,7,23]],"date-time":"2027-07-23T00:00:00Z","timestamp":1816300800000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.science.org\/content\/page\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1HG011585"],"award-info":[{"award-number":["UM1HG011585"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 HL157989"],"award-info":[{"award-number":["U01 HL157989"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 HL157989"],"award-info":[{"award-number":["U01 HL157989"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 HL157989"],"award-info":[{"award-number":["U01 HL157989"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL155906"],"award-info":[{"award-number":["R01 HL155906"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL155906"],"award-info":[{"award-number":["R01 HL155906"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020415","name":"Additional Ventures","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020415","name":"Additional Ventures","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020415","name":"Additional Ventures","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008072","name":"Gladstone Institutes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009724","name":"Roddenberry Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009724","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Younger Family Fund"},{"DOI":"10.13039\/100008072","name":"Gladstone Institutes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009724","name":"Roddenberry Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009724","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020415","name":"Additional Ventures","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008072","name":"Gladstone Institutes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009364","name":"Saving Tiny Hearts Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009364","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UCSF Pediatric Heart Center"}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2026,7,23]]},"abstract":"<jats:p>\n                    Dosage-sensitive transcription factors (TFs) underlie altered gene regulation in human developmental disorders, and cell type\u2013specific gene regulation is linked to the reorganization of three-dimensional (3D) chromatin during cellular differentiation. In this work, we show dose-dependent regulation of chromatin organization by the congenital heart disease (CHD)\u2013linked, lineage-restricted TF TBX5 in human cardiomyocyte differentiation. Genome organization, including compartments, topologically associated domains, and chromatin loops, was sensitive to reduced\n                    <jats:italic toggle=\"yes\">TBX5<\/jats:italic>\n                    dosage in a human model of CHD, with variations in response across individual cells. Cohesin binding was reduced at TBX5-bound enhancer elements in a TBX5 dose-dependent manner, providing a potential mechanism for disrupted loop formation. These results highlight the importance of lineage-restricted TF dosage in cell type\u2013specific 3D chromatin dynamics, suggesting a mechanism for TF-dependent disease.\n                  <\/jats:p>","DOI":"10.1126\/science.adv5434","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:07:49Z","timestamp":1784830069000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease\u2013linked transcription factor"],"prefix":"10.1126","volume":"393","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0580-5222","authenticated-orcid":true,"given":"Zoe L.","family":"Grant","sequence":"first","affiliation":[{"name":"Gladstone Institutes, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3844-3647","authenticated-orcid":true,"given":"Shuzhen","family":"Kuang","sequence":"additional","affiliation":[{"name":"Gladstone Institutes, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6592-118X","authenticated-orcid":true,"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Gladstone Institutes, San Francisco, CA, USA."},{"name":"Bioinformatics Graduate Program, University of California, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6334-7229","authenticated-orcid":true,"given":"Abraham J.","family":"Horrillo","sequence":"additional","affiliation":[{"name":"Gladstone Institutes, San Francisco, CA, USA."},{"name":"TETRAD Graduate Program, University of California, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6605-8237","authenticated-orcid":true,"given":"Zhe","family":"Chen","sequence":"additional","affiliation":[{"name":"Gladstone Institutes, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5401-6989","authenticated-orcid":true,"given":"Kavitha S.","family":"Rao","sequence":"additional","affiliation":[{"name":"Gladstone Institutes, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8308-3750","authenticated-orcid":true,"given":"Cemre","family":"Celen","sequence":"additional","affiliation":[{"name":"Gladstone Institutes, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2552-6183","authenticated-orcid":true,"given":"Vasumathi","family":"Kameswaran","sequence":"additional","affiliation":[{"name":"Gladstone Institutes, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8747-6954","authenticated-orcid":true,"given":"Carine","family":"Joubran","sequence":"additional","affiliation":[{"name":"Gladstone Institutes, San Francisco, CA, USA."},{"name":"Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pik Ki","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, CA, USA."},{"name":"Center for Epigenomics, University of California, San Diego, School of Medicine, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8662-4706","authenticated-orcid":true,"given":"Keyi","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, CA, USA."},{"name":"Center for Epigenomics, University of California, San Diego, School of Medicine, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8590-5358","authenticated-orcid":true,"given":"Bing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, CA, USA."},{"name":"Center for Epigenomics, University of California, San Diego, School of Medicine, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7724-5216","authenticated-orcid":true,"given":"Weronika M.","family":"Bartosik","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, CA, USA."},{"name":"Center for Epigenomics, University of California, San Diego, School of Medicine, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6326-5925","authenticated-orcid":true,"given":"Nathan R.","family":"Zemke","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, CA, USA."},{"name":"Center for Epigenomics, University of California, San Diego, School of Medicine, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5435-1127","authenticated-orcid":true,"given":"Bing","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, CA, USA."},{"name":"Center for Epigenomics, University of California, San Diego, School of Medicine, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3480-5953","authenticated-orcid":true,"given":"Deepak","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Gladstone Institutes, San Francisco, CA, USA."},{"name":"Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA, USA."},{"name":"Department of Pediatrics and Biochemistry, University of California, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1207-1490","authenticated-orcid":true,"given":"Irfan S.","family":"Kathiriya","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9870-6196","authenticated-orcid":true,"given":"Katherine S.","family":"Pollard","sequence":"additional","affiliation":[{"name":"Gladstone Institutes, San Francisco, CA, USA."},{"name":"Department of Epidemiology &amp; Biostatistics, University of California, San Francisco, CA, USA."},{"name":"Chan Zuckerberg Biohub, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0804-7597","authenticated-orcid":true,"given":"Benoit G.","family":"Bruneau","sequence":"additional","affiliation":[{"name":"Gladstone Institutes, San Francisco, CA, USA."},{"name":"Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA, USA."},{"name":"Department of Pediatrics, Cardiovascular Research Institute, Institute for Human Genetics, and the Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31763"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215043"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.10.026"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.09.030"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0128-0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2151-x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1182-7"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19283-x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.004"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05961-5"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.317004"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.12.028"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.10.023"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0234-8"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42647-y"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26159-1"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27865-6"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01232-z"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10318-6"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00493-7"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.11.020"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.05.023"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0197-30"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0197-21"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.511"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.517"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.168294"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","unstructured":"I. S. Kathiriya K. S. Rao A. P. Clark K. M. Hu Z. L. Grant M. N. Matthews Z. Chen S. K. Hota J. J. Saucerman B. G. Bruneau Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease. bioRxiv 2025.08.16.669546 [Preprint] (2025); https:\/\/doi.org\/10.1101\/2025.08.16.669546.","DOI":"10.1101\/2025.08.16.669546"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09483-5"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0479-7"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01248-7"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.11.025"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.99941"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2008.11.003"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0547-z"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0502-z"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.01.004"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2016.01.009"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.07.002"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.11.033"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-022-00787-7"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.06.008"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2110991118"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2434235100"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.317045"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.050432"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.136507.111"},{"key":"e_1_3_2_49_2","doi-asserted-by":"crossref","unstructured":"4D Nucleome Consortium An integrated view of the structure and function of the human 4D nucleome. bioRxiv 2024.09.17.613111 [Preprint] (2024); https:\/\/doi.org\/10.1101\/2024.09.17.613111.","DOI":"10.1101\/2024.09.17.613111"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b00171"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-023-00334-7"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03071"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1187"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1689708"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2020.01.003"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01366-2"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1400648111"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-018-0021-8"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.220640.117"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1012067"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.11.021"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17239-9"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34626-6"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03182-8"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06819-6"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2022.09.004"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz540"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-021-01034-y"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0439-x"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4197"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty560"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0201-4"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq033"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-9-r137"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw257"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp335"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1113"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.adv5434","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.adv5434","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:08:41Z","timestamp":1784830121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.adv5434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":81,"journal-issue":{"issue":"6809","published-print":{"date-parts":[[2026,7,23]]}},"alternative-id":["10.1126\/science.adv5434"],"URL":"https:\/\/doi.org\/10.1126\/science.adv5434","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]},"assertion":[{"value":"2024-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadv5434"}}