{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T16:55:32Z","timestamp":1794243332659,"version":"4.9.0"},"reference-count":90,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6773","funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE 1762114"],"award-info":[{"award-number":["DGE 1762114"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1F30HL163926"],"award-info":[{"award-number":["1F30HL163926"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL128368"],"award-info":[{"award-number":["R01 HL128368"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["SFB1002A08"],"award-info":[{"award-number":["SFB1002A08"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute of Health","award":["FHL 165834A"],"award-info":[{"award-number":["FHL 165834A"]}]},{"name":"National Institute of Health","award":["P30 AR074990"],"award-info":[{"award-number":["P30 AR074990"]}]},{"name":"National Institute of Health","award":["R01 HL146868"],"award-info":[{"award-number":["R01 HL146868"]}]},{"name":"National Institute of Health","award":["RM1 GM131981"],"award-info":[{"award-number":["RM1 GM131981"]}]},{"name":"National Institute of Health","award":["R01 HL157169"],"award-info":[{"award-number":["R01 HL157169"]}]},{"name":"National Institute of Health","award":["R01 HL142624"],"award-info":[{"award-number":["R01 HL142624"]}]},{"name":"National Institute of Health","award":["HL141187"],"award-info":[{"award-number":["HL141187"]}]},{"name":"National Institute of Health","award":["HL162229"],"award-info":[{"award-number":["HL162229"]}]},{"name":"National Institute of Healtht","award":["R01 HL149734"],"award-info":[{"award-number":["R01 HL149734"]}]},{"name":"National Institute of Health","award":["R35 GM138036"],"award-info":[{"award-number":["R35 GM138036"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2025,11,6]]},"abstract":"<jats:p>Cardiomyocyte hypocontractility underlies inherited dilated cardiomyopathy (DCM). Yet, whether fibroblasts modify DCM phenotypes remains unclear despite their regulation of fibrosis, which strongly predicts disease severity. Expression of a hypocontractility-linked sarcomeric variant in mice triggered cardiac fibroblast expansion from the de novo formation of hyperproliferative mechanosensitized fibroblast states, which occurred prior to eccentric myocyte remodeling. Initially, this fibroblast response reorganized fibrillar collagen and stiffened the myocardium, albeit without depositing fibrotic tissue. These adaptations coincided with heightened matrix\u2013integrin receptor interactions and diastolic tension sensation at focal adhesions within fibroblasts. Targeted p38 deletion arrested these cardiac fibroblast responses in DCM mice, which prevented cardiomyocyte remodeling and improved contractility. p38-mediated fibroblast responses were essential regulators of DCM severity, marking a potential cellular target for therapeutic intervention.<\/jats:p>","DOI":"10.1126\/science.adv9157","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:59:12Z","timestamp":1757613552000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":16,"title":["Preventing hypocontractility-induced fibroblast expansion alleviates dilated cardiomyopathy"],"prefix":"10.1126","volume":"390","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9567-8556","authenticated-orcid":true,"given":"Ross C.","family":"Bretherton","sequence":"first","affiliation":[{"name":"Department of Bioengineering, University of Washington, Seattle, WA, USA."},{"name":"Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA."},{"name":"Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5637-8166","authenticated-orcid":true,"given":"Isabella M.","family":"Reichardt","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Washington, Seattle, WA, USA."},{"name":"Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA."},{"name":"Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4832-8906","authenticated-orcid":true,"given":"Kristin A.","family":"Zabrecky","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA."},{"name":"Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA."},{"name":"Department of Comparative Medicine, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6200-8628","authenticated-orcid":true,"given":"Abigail","family":"Nagle","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Washington, Seattle, WA, USA."},{"name":"Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA."},{"name":"Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7811-7362","authenticated-orcid":true,"given":"Logan R. J.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA."},{"name":"Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA."},{"name":"Department of Lab Medicine and Pathology, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0930-6175","authenticated-orcid":true,"given":"Darrian","family":"Bugg","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA."},{"name":"Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA."},{"name":"Department of Lab Medicine and Pathology, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7735-9922","authenticated-orcid":true,"given":"Sasha","family":"Smolgovsky","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA."},{"name":"Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA."},{"name":"Department of Lab Medicine and Pathology, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8773-0346","authenticated-orcid":true,"given":"Amy L.","family":"Gifford","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA."},{"name":"Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA."},{"name":"Department of Lab Medicine and Pathology, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5261-3229","authenticated-orcid":true,"given":"Timothy S.","family":"McMillen","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Washington, Seattle, WA, USA."},{"name":"Department of Anesthesiology, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex J.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA."},{"name":"Department of Lab Medicine and Pathology, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1817-9080","authenticated-orcid":true,"given":"Kristina B.","family":"Kooiker","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA."},{"name":"Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA."},{"name":"Division of Cardiology, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3993-5156","authenticated-orcid":true,"given":"Galina V.","family":"Flint","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5797-4689","authenticated-orcid":true,"given":"Amy","family":"Martinson","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA."},{"name":"Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA."},{"name":"Department of Lab Medicine and Pathology, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagdambika","family":"Gunaje","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA."},{"name":"Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA."},{"name":"Department of Lab Medicine and Pathology, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9585-0935","authenticated-orcid":true,"given":"Franziska","family":"Koser","sequence":"additional","affiliation":[{"name":"Institute of Physiology II, University of M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Plaster","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA."},{"name":"Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA."},{"name":"Department of Lab Medicine and Pathology, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0801-3773","authenticated-orcid":true,"given":"Wolfgang A.","family":"Linke","sequence":"additional","affiliation":[{"name":"Institute of Physiology II, University of M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5437-9851","authenticated-orcid":true,"given":"Michael","family":"Regnier","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Washington, Seattle, WA, USA."},{"name":"Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA."},{"name":"Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA."},{"name":"Center for Translational Muscle Research, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0189-7214","authenticated-orcid":true,"given":"Farid","family":"Moussavi-Harami","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA."},{"name":"Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA."},{"name":"Department of Lab Medicine and Pathology, University of Washington, Seattle, WA, USA."},{"name":"Division of Cardiology, University of Washington, Seattle, WA, USA."},{"name":"Center for Translational Muscle Research, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6960-4492","authenticated-orcid":true,"given":"Nathan J.","family":"Sniadecki","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Washington, Seattle, WA, USA."},{"name":"Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA."},{"name":"Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA."},{"name":"Department of Lab Medicine and Pathology, University of Washington, Seattle, WA, USA."},{"name":"Center for Translational Muscle Research, University of Washington, Seattle, WA, USA."},{"name":"Department of Mechanical Engineering, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0337-3577","authenticated-orcid":true,"given":"Cole A.","family":"DeForest","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Washington, Seattle, WA, USA."},{"name":"Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA."},{"name":"Department of Chemical Engineering, University of Washington, Seattle, WA, USA."},{"name":"Department of Chemistry, University of Washington, Seattle, WA, USA."},{"name":"Molecular Engineering &amp; Sciences Institute, University of Washington, Seattle, WA, USA."},{"name":"Institute for Protein Design, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2380-1321","authenticated-orcid":true,"given":"Jennifer","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Washington, Seattle, WA, USA."},{"name":"Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA."},{"name":"Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA."},{"name":"Department of Lab Medicine and Pathology, University of Washington, Seattle, WA, USA."},{"name":"Center for Translational Muscle Research, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.04.002"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.142446"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-083118-015306"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412083312307"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2013.105"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI62862"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2025797"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.052359"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-019-02269-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.118.007722"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.07.015"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2020.11.006"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.079970"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.303794"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12260"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI74783"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2020.04.002"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3896"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0155-8"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.10.025"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405413200"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2016.05.001"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.942268"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.231514"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.01.005"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-017-0263-9"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000007"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004903"},{"key":"e_1_3_2_30_2","first-page":"3525","article-title":"Collagen VI at a glance","volume":"128","author":"Cescon M.","year":"2015","unstructured":"M. Cescon, F. Gattazzo, P. Chen, P. Bonaldo, Collagen VI at a glance. J. Cell Sci. 128, 3525\u20133531 (2015). 26377767","journal-title":"J. Cell Sci."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2200091"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00168.2002"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60250-9"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05199-3"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-73906-9"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.08.003"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.08.035"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.1449904"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.106.097998"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2010.10.001"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20776"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2013.04.004"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109888"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.57"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.01.012"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10084"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.026238"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2009119117"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-014-0581-9"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2016.0257"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345241264792"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.329763.119"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.03.019"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3581"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.316162"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.4131"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023539"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-024-00493-1"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.07.010"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature21348"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.008"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3524"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-022-00799-2"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2011.09.057"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI98215"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00054.2019"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69854"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2019.09.003"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.262717"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.4103\/2153-3539.139707"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7113-8_28"},{"key":"e_1_3_2_73_2","doi-asserted-by":"crossref","unstructured":"M. Pachitariu M. Rariden C. Stringer Cellpose-SAM: superhuman generalization for cellular segmentation. bioRxiv 2025.04.28.651001 [Preprint] (2025); https:\/\/doi.org\/10.1101\/2025.04.28.651001.","DOI":"10.1101\/2025.04.28.651001"},{"key":"e_1_3_2_74_2","unstructured":"F. Pedregosa et al. \u201cScikit-Learn: Machine Learning in Python.\u201d Journal of Machine Learning Research vol. 12 no. 85 2011 pp. 2825\u201330."},{"key":"e_1_3_2_75_2","unstructured":"Waskom Michael et al. \u201cSeaborn: Statistical Data Visualization.\u201d Astrophysics Source Code Library Dec. 2020 p. ascl:2012.015."},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.08.017"},{"key":"e_1_3_2_77_2","first-page":"103","article-title":"Collagen gel contraction assay","volume":"341","author":"Ngo P.","year":"2006","unstructured":"P. Ngo, R. Ramalingam, J. A. Phillips, G. T. Furuta, Collagen gel contraction assay. Methods Mol Biol 341, 103\u2013109 (2006).","journal-title":"Methods Mol Biol"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4219"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9LC00621D"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz369"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-022-00752-0"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.066860"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2018.11.005"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4096"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-2261-2_6"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09198"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33927"}],"updated-by":[{"DOI":"10.1126\/science.aej2323","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000}}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.adv9157","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.adv9157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:00:27Z","timestamp":1780596027000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.adv9157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":90,"journal-issue":{"issue":"6773","published-print":{"date-parts":[[2025,11,6]]}},"alternative-id":["10.1126\/science.adv9157"],"URL":"https:\/\/doi.org\/10.1126\/science.adv9157","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,6]]},"assertion":[{"value":"2025-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadv9157"}}