{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:36:01Z","timestamp":1790138161565,"version":"4.0.1"},"reference-count":89,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6792","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI110818"],"award-info":[{"award-number":["U19AI110818"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI110112"],"award-info":[{"award-number":["R01AI110112"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["INV-009416"],"award-info":[{"award-number":["INV-009416"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-18-CE15-0007"],"award-info":[{"award-number":["ANR-18-CE15-0007"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303382\/2022-8"],"award-info":[{"award-number":["303382\/2022-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2026,3,26]]},"abstract":"<jats:p>\n                    Malaria in South America remains a serious public health problem.\n                    <jats:italic toggle=\"yes\">Anopheles<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">Nyssorhynchus<\/jats:italic>\n                    )\n                    <jats:italic toggle=\"yes\">darlingi<\/jats:italic>\n                    is the most important malaria vector across tropical Latin America. Vector-targeted disease control efforts require a thorough understanding of mosquito demographic and evolutionary patterns. We present and analyze whole genomes of 1094\n                    <jats:italic toggle=\"yes\">An. darlingi<\/jats:italic>\n                    (median depth 18x) from six South American countries. We observe deep geographic population structure, high genetic diversity including 13 putative segregating inversions, and no evidence for sympatric cryptic taxa despite high interpopulation divergence. Strong signals of selection are plausibly driven by insecticides, especially on cytochrome P450 genes. Our results will facilitate effective mosquito surveillance and control while highlighting ongoing challenges that a diverse vector poses for malaria elimination in the Western hemisphere.\n                  <\/jats:p>","DOI":"10.1126\/science.adw9761","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T18:00:46Z","timestamp":1774548046000},"page":"1373-1378","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Population genomics of\n                    <i>Anopheles darlingi<\/i>\n                    , the principal South American malaria vector mosquito"],"prefix":"10.1126","volume":"391","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5015-4740","authenticated-orcid":true,"given":"Jacob A.","family":"Tennessen","sequence":"first","affiliation":[{"name":"Harvard T.H. Chan School of Public Health, Boston, MA, USA."},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1571-9390","authenticated-orcid":true,"given":"Raphael","family":"Brosula","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Chabanol","sequence":"additional","affiliation":[{"name":"Institut Pasteur de la Guyane, Cayenne, French Guiana."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2748-0425","authenticated-orcid":true,"given":"Sara","family":"Bickersmith","sequence":"additional","affiliation":[{"name":"New York State Department of Health, Wadsworth Center, Albany, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Early","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7053-983X","authenticated-orcid":true,"given":"Margaret","family":"Laws","sequence":"additional","affiliation":[{"name":"Harvard T.H. Chan School of Public Health, Boston, MA, USA."},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina A.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Harvard T.H. Chan School of Public Health, Boston, MA, USA."},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2922-6751","authenticated-orcid":true,"given":"Maria Eugenia","family":"Grillet","sequence":"additional","affiliation":[{"name":"Instituto de Zoolog\u00eda y Ecolog\u00eda Tropical, Facultad de Ciencias, Universidad Central de Venezuela, Caracas, Venezuela."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1420-7729","authenticated-orcid":true,"given":"Dionicia","family":"Gamboa","sequence":"additional","affiliation":[{"name":"Laboratorio de Malaria: Par\u00e1sitos y Vectores, Laboratorios de Investigaci\u00f3n y Desarrollo, Facultad de Ciencias e Ingenier\u00eda, Universidad Peruana Cayetano Heredia, Lima, Peru."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3892-1668","authenticated-orcid":true,"given":"Eric R.","family":"Lucas","sequence":"additional","affiliation":[{"name":"Liverpool School of Tropical Medicine, Liverpool, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5044-4855","authenticated-orcid":true,"given":"Jean-Bernard","family":"Duchemin","sequence":"additional","affiliation":[{"name":"Institut Pasteur de la Guyane, Cayenne, French Guiana."},{"name":"Arboviruses and Insect Vectors, Institut Pasteur, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5204-7693","authenticated-orcid":true,"given":"Martha L.","family":"Qui\u00f1ones","sequence":"additional","affiliation":[{"name":"Universidad Nacional de Colombia, Bogot\u00e1, Colombia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7051-2891","authenticated-orcid":true,"given":"Maria Anice Mureb","family":"Sallum","sequence":"additional","affiliation":[{"name":"Faculdade de Sa\u00fade P\u00fablica, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4928-0368","authenticated-orcid":true,"given":"Eduardo S.","family":"Bergo","sequence":"additional","affiliation":[{"name":"Instituto Pasteur de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0584-7078","authenticated-orcid":true,"given":"Jorge E.","family":"Moreno","sequence":"additional","affiliation":[{"name":"Instituto de Altos Estudios Dr. Arnoldo Gabald\u00f3n, Centro de Investigaciones de Campo Francesco Vitanza, Bolivar, Venezuela."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1214-8523","authenticated-orcid":true,"given":"Sanjay","family":"Nagi","sequence":"additional","affiliation":[{"name":"Liverpool School of Tropical Medicine, Liverpool, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Arisco","sequence":"additional","affiliation":[{"name":"Harvard T.H. Chan School of Public Health, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9129-6956","authenticated-orcid":true,"given":"Mohini","family":"Sooklall","sequence":"additional","affiliation":[{"name":"Vector Control Services, Ministry of Health, Georgetown, Guyana."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5948-4335","authenticated-orcid":true,"given":"Reza","family":"Niles-Robin","sequence":"additional","affiliation":[{"name":"Vector Control Services, Ministry of Health, Georgetown, Guyana."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4606-2795","authenticated-orcid":true,"given":"Marcia C.","family":"Castro","sequence":"additional","affiliation":[{"name":"Harvard T.H. Chan School of Public Health, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9127-4212","authenticated-orcid":true,"given":"Horace","family":"Cox","sequence":"additional","affiliation":[{"name":"Vector Control Services, Ministry of Health, Georgetown, Guyana."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6405-6458","authenticated-orcid":true,"given":"Mathilde","family":"Gendrin","sequence":"additional","affiliation":[{"name":"Institut Pasteur de la Guyane, Cayenne, French Guiana."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5301-7020","authenticated-orcid":true,"given":"Jan E.","family":"Conn","sequence":"additional","affiliation":[{"name":"New York State Department of Health, Wadsworth Center, Albany, NY, USA."},{"name":"Department of Biomedical Sciences, College of Integrated Health Sciences, State University of New York at Albany, Albany, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1665-9323","authenticated-orcid":true,"given":"Daniel E.","family":"Neafsey","sequence":"additional","affiliation":[{"name":"Harvard T.H. Chan School of Public Health, Boston, MA, USA."},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization World Malaria Report 2024 (WHO 2024); https:\/\/www.who.int\/teams\/global-malaria-programme\/reports\/world-malaria-report-2024."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008211"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature00813"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv752"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.51015"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761996000400001"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/20477724.2019.1581463"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","unstructured":"R. E. Harbach \u201cThe phylogeny and classification of Anopheles\u201d in Anopheles Mosquitoes: New Insights into Malaria Vectors S. Manguin Ed. (IntechOpen 2013) pp. 3\u201355.","DOI":"10.5772\/54695"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.170758"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134462"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24995"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.262790.120"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-04259-y"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.adu3596"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2016.01.004"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8312.2009.01226.x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130773"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1258524"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2018142117"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/178863a0"},{"key":"e_1_3_2_22_2","first-page":"625","article-title":"Anopheles gambiae, a complex of species","volume":"31","author":"Davidson G.","year":"1964","unstructured":"G. Davidson, Anopheles gambiae, a complex of species. Bull. World Health Organ. 31, 625\u2013634 (1964). 14278001","journal-title":"Bull. World Health Organ."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-017-4086-7"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2020.104666"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-17822-8"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes14101892"},{"key":"e_1_3_2_27_2","first-page":"72","article-title":"First record of DDT resistance in Anopheles darlingi","volume":"6","author":"Suarez M. F.","year":"1990","unstructured":"M. F. Suarez, M. L. Qui\u00f1ones, J. D. Palacios, A. Carrillo, First record of DDT resistance in Anopheles darlingi. J. Am. Mosq. Control Assoc. 6, 72\u201374 (1990). 2324727","journal-title":"J. Am. Mosq. Control Assoc."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9163543"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.20-1611"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-025-05385-8"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.hdy.6800805"},{"key":"e_1_3_2_32_2","first-page":"286","article-title":"Geographical distribution of Anopheles darlingi in the Amazon Basin region of Peru","volume":"19","author":"Schoeler G. B.","year":"2003","unstructured":"G. B. Schoeler, C. Flores-Mendoza, R. Fern\u00e1ndez, J. R. Davila, M. Zyzak, Geographical distribution of Anopheles darlingi in the Amazon Basin region of Peru. J. Am. Mosq. Control Assoc. 19, 286\u2013296 (2003). 14710728","journal-title":"J. Am. Mosq. Control Assoc."},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0863-4"},{"key":"e_1_3_2_34_2","first-page":"5","article-title":"Linking deforestation to malaria in the Amazon: Characterization of the breeding habitat of the principal malaria vector, Anopheles darlingi","volume":"81","author":"Vittor A. Y.","year":"2009","unstructured":"A. Y. Vittor, W. Pan, R. H. Gilman, J. Tielsch, G. Glass, T. Shields, W. S\u00e1nchez-Lozano, V. V. Pinedo, E. Salas-Cobos, S. Flores, J. A. Patz, Linking deforestation to malaria in the Amazon: Characterization of the breeding habitat of the principal malaria vector, Anopheles darlingi. Am. J. Trop. Med. Hyg. 81, 5\u201312 (2009). 19556558","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005337"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00129"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760150470"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/jhered\/esq054"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evad060"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/mec.12164"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44358-024-00001-0"},{"key":"e_1_3_2_42_2","first-page":"468","article-title":"Molecular population genetics of the primary neotropical malaria vector Anopheles darlingi using mtDNA","volume":"15","author":"Conn J. E.","year":"1999","unstructured":"J. E. Conn, M. G. Rosa-Freitas, S. L. Luz, H. Momen, Molecular population genetics of the primary neotropical malaria vector Anopheles darlingi using mtDNA. J. Am. Mosq. Control Assoc. 15, 468\u2013474 (1999). 10612610","journal-title":"J. Am. Mosq. Control Assoc."},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1622-4"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1603\/0022-2585-39.6.861"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2012.11-0414"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes9030140"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/mec.16591"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.165992"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-023-05876-0"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-56732-x"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-538"},{"key":"e_1_3_2_52_2","doi-asserted-by":"crossref","unstructured":"S. C. Nagi N. J. Harding M. K. N. Lawniczak M. J. Donnelly A. Miles. An atlas of positive selection in the genomes of major malaria vectors. bioRxiv 2025.07.16.664900 [Preprint] (2025). https:\/\/doi.org\/10.1101\/2025.07.16.664900.","DOI":"10.1101\/2025.07.16.664900"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3002898"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-024-02081-y"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4245"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/ece3.10782"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0804-2"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/1755-0998.13436"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/1755-0998.14088"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.23989.1"},{"key":"e_1_3_2_61_2","doi-asserted-by":"crossref","unstructured":"M. Vasimuddin S. Misra H. Li S. Aluru \u201cEfficient architecture-aware acceleration of BWA-MEM for multicore systems.\u201d in 2019 IEEE International Parallel and Distributed Processing Symposium Rio de Janeiro Brazil 20 to 24 May 2019 (IPDPS 2019) pp. 314\u2013324.","DOI":"10.1109\/IPDPS.2019.00041"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giab008"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.107524.110"},{"key":"e_1_3_2_64_2","doi-asserted-by":"crossref","unstructured":"R. Poplin V. Ruano-Rubio M. A. DePristo T. J. Fennell M. O. Carneiro G. A. Van der Auwera D. E. Kling L. D. Gauthier A. Levy-Moonshine D. Roazen K. Shakir J. Thibault S. Chandran C. Whelan M. Lek S. Gabriel M. J. Daly B. Neale D. G. MacArthur E. Banks Scaling accurate genetic variant discovery to tens of thousands of samples. bioRxiv 201178 [Preprint] (2018). https:\/\/doi.org\/10.1101\/201178.","DOI":"10.1101\/201178"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cois.2021.11.008"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts606"},{"key":"e_1_3_2_67_2","unstructured":"R Core Team R: A Language and Environment for Statistical Computing (R Foundation for Statistical Computing version 4.4.2 2024); https:\/\/www.R-project.org."},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msh252"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-020-02196-9"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.113.158758"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0717-7"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msaa169"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu033"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.245795.118"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.094052.109"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw327"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1010410"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.61927"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.154831.113"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/145.4.1219"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v022.i04"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.118.301502"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.120.303780"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.3390\/rs12172735"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.7705\/biomedica.v32i0.455"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-019-3739-6"},{"key":"e_1_3_2_87_2","unstructured":"World Health Organization \u201cGlobal report on insecticide resistance in malaria vectors: 2010\u20132016\u201d (WHO 2018); https:\/\/www.who.int\/publications\/i\/item\/9789241514057"},{"key":"e_1_3_2_88_2","first-page":"25","article-title":"Malaria eradication under continental equatorial conditions in Guyana","volume":"23","author":"Giglioli G.","year":"1974","unstructured":"G. Giglioli, W. I. Ch\u2019en, P. Howell, D. Marchant, Malaria eradication under continental equatorial conditions in Guyana. West Indian Med. J. 23, 25\u201334 (1974). 4456817","journal-title":"West Indian Med. J."},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760170398"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760220210"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.adw9761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T18:01:33Z","timestamp":1774548093000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.adw9761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,26]]},"references-count":89,"journal-issue":{"issue":"6792","published-print":{"date-parts":[[2026,3,26]]}},"alternative-id":["10.1126\/science.adw9761"],"URL":"https:\/\/doi.org\/10.1126\/science.adw9761","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,26]]},"assertion":[{"value":"2025-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-27","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}