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Although endogenous \u03b3\u03b4T cell antigen receptor (\u03b3\u03b4TCR) ligands are thought to regulate \u03b3\u03b4T cell development, their identities are largely elusive. Here, we identified the interleukin 17 receptor A chain (IL17RA) as a \u03b3\u03b4TCR ligand that drove the differentiation of V\u03b47\n                    <jats:sup>+<\/jats:sup>\n                    \u03b3\u03b4T cells with a T helper 1 (T\n                    <jats:sub>H<\/jats:sub>\n                    1)\u2013like effector program in mice. IL17RA promoted this differentiation through an interaction involving germline-encoded regions of the V\u03b47 chain, enabling the selection of cells with a diverse CDR3 repertoire and thus acting as a nonclonotypic \u03b3\u03b4TCR ligand. Together with the nonclonotypic mode of \u03b3\u03b4TCR engagement by butyrophilins, these results suggest that such interactions represent a general biological mechanism shaping the \u03b3\u03b4T cell compartment.\n                  <\/jats:p>","DOI":"10.1126\/science.adx9264","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:03:38Z","timestamp":1784225018000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Direct interaction of V\u03b47 TCRs with IL17RA drives the differentiation of T\n                    <sub>H<\/sub>\n                    1-like \u03b3\u03b4T cells"],"prefix":"10.1126","volume":"393","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3140-741X","authenticated-orcid":true,"given":"Kewei","family":"Ye","sequence":"first","affiliation":[{"name":"Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, Karolinska 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