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They form a core fertilization complex, but it is unknown how they interact. We determined a cryo\u2013electron microscopy structure of the endogenous Pfs230-Pfs48\/45 complex showing that Pfs48\/45 interacts with Pfs230 domains 13 and 14. Transgenic parasite lines with these domains removed were defective in Pfs230 gamete localization and showed reduced oocyst formation. Nanobodies against domains 13 and 14 inhibited Pfs230-Pfs48\/45 complex formation and reduced transmission, and structural analyses revealed their epitopes. 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