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Using spatial transcriptomics and multiplex imaging across human tumors, we found that CCR7\n                    <jats:sup>+<\/jats:sup>\n                    mature dendritic cells (DCs) accumulate in TLSs. In a mouse non\u2013small cell lung cancer model that forms mature TLSs, we show that early TLS development requires interferon-\u03b3 (IFN-\u03b3)\u2013driven type 1 conventional dendritic cell (cDC1) maturation, migration to tumor-draining lymph nodes (tdLNs), and T cell recruitment. As tumors progress, TLSs persist independently of tdLN T cell egress, coinciding with cDC1 accumulation within intratumoral CCL19 stromal hubs. There, cDC1\u2013major histocompatibility complex class 1 (MHC-I) and \u2013MHC-II concomitant antigen presentation, along with CD40 signaling, sustain TLS, T follicular helper (T\n                    <jats:sub>FH<\/jats:sub>\n                    ) cell pool, germinal centers, and tumor-specific immunoglobulin G (IgG). These findings highlight local mature cDC1s as key TLS orchestrators and potential targets to enhance antitumor TLS function.\n                  <\/jats:p>","DOI":"10.1126\/science.ady1678","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:03:38Z","timestamp":1784225018000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":12,"title":["Dendritic cells control tertiary lymphoid structure development and maintenance in cancer"],"prefix":"10.1126","volume":"393","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3292-1635","authenticated-orcid":true,"given":"Rapha\u00ebl","family":"Mattiuz","sequence":"first","affiliation":[{"name":"Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA."},{"name":"Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, 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