{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T10:28:32Z","timestamp":1792578512770,"version":"4.5.0"},"reference-count":84,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6779","funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["ZIA-MH002793"],"award-info":[{"award-number":["ZIA-MH002793"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM146765"],"award-info":[{"award-number":["R35GM146765"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R01EB036046"],"award-info":[{"award-number":["R01EB036046"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2025,12,18]]},"abstract":"<jats:p>\n                    Continued development of positron emission tomography (PET) tracers is essential for advancing molecular imaging in biomedical research and clinical diagnostics. A long-standing limitation in radiochemistry for PET imaging has been the lack of general methods for radiolabeling trifluoromethyl (CF\n                    <jats:sub>3<\/jats:sub>\n                    ) groups at C(sp\n                    <jats:sup>3<\/jats:sup>\n                    ) sites, despite their growing prevalence in bioactive molecules and radiopharmaceuticals. Here, we present a general approach for late-stage installation of either a [\n                    <jats:sup>18<\/jats:sup>\n                    F]CF\n                    <jats:sub>3<\/jats:sub>\n                    or [\n                    <jats:sup>11<\/jats:sup>\n                    C]CF\n                    <jats:sub>3<\/jats:sub>\n                    group at a C(sp\n                    <jats:sup>3<\/jats:sup>\n                    ) site. This method leverages unusual copper-mediated radiotrifluoromethylation of alkyl halides and alkyl carboxylic acids by halogen atom transfer and photoredox catalysis, respectively. More than 50 complex molecules and pharmaceutical agents were efficiently labeled with fluorine-18 (\n                    <jats:sup>18<\/jats:sup>\n                    F) or carbon-11 (\n                    <jats:sup>11<\/jats:sup>\n                    C). Two long-sought-after radioligands, [\n                    <jats:sup>18<\/jats:sup>\n                    F]SL25.1188 and [\n                    <jats:sup>18<\/jats:sup>\n                    F]PS13, were synthesized, providing longer-lived\n                    <jats:sup>18<\/jats:sup>\n                    F analogs of their\n                    <jats:sup>11<\/jats:sup>\n                    C counterparts with great promise for human PET imaging.\n                  <\/jats:p>","DOI":"10.1126\/science.ady2969","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:02:29Z","timestamp":1766084549000},"page":"1278-1284","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":8,"title":["Trifluoromethylation of alkyl electrophiles with\n                    <sup>11<\/sup>\n                    C- or\n                    <sup>18<\/sup>\n                    F-labeled fluoroform for PET applications"],"prefix":"10.1126","volume":"390","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0488-1670","authenticated-orcid":true,"given":"Chao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Cincinnati, Cincinnati, OH, USA."},{"name":"Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA."},{"name":"Department of Chemistry, Virginia Tech, Blacksburg, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"DeMent","sequence":"additional","affiliation":[{"name":"Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9910-347X","authenticated-orcid":true,"given":"Susovan","family":"Jana","sequence":"additional","affiliation":[{"name":"Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0450-6258","authenticated-orcid":true,"given":"Jinsoo","family":"Hong","sequence":"additional","affiliation":[{"name":"Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9032-2553","authenticated-orcid":true,"given":"Victor W.","family":"Pike","sequence":"additional","affiliation":[{"name":"Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6249-3179","authenticated-orcid":true,"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Cincinnati, Cincinnati, OH, USA."},{"name":"Department of Chemistry, Virginia Tech, Blacksburg, VA, 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