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We identified mechanically activated ion channels PIEZO1 and PIEZO2 as key mechanotransducers required for labor progression. Genetic deletion of\n                    <jats:italic toggle=\"yes\">Piezo1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Piezo2<\/jats:italic>\n                    in mice resulted in weakened uterine contractions and severe parturition defects. Tissue-specific knockouts revealed that deletion in either uterus or sensory neurons alone caused modest defects whereas combined loss markedly impaired labor, demonstrating additive effects. Single-nuclei sequencing indicated that loss of PIEZO function reduced expression of connexin43 (\n                    <jats:italic toggle=\"yes\">Gja1<\/jats:italic>\n                    ), a gap junction protein in uterine smooth muscle cells, suggesting a mechanistic link to impaired contraction. These findings highlight the critical role of PIEZO channels in mechanotransduction during parturition and suggest therapeutic targets for labor dysfunction.\n                  <\/jats:p>","DOI":"10.1126\/science.ady3045","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T19:02:59Z","timestamp":1763060579000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":20,"title":["PIEZO channels link mechanical forces to uterine contractions in parturition"],"prefix":"10.1126","volume":"390","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2145-4151","authenticated-orcid":true,"given":"Yunxiao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, San Diego, CA, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6551-9104","authenticated-orcid":true,"given":"Sejal A.","family":"Kini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, San Diego, CA, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7703-0705","authenticated-orcid":true,"given":"Sassan A.","family":"Mishkanian","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, San Diego, CA, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8215-7444","authenticated-orcid":true,"given":"Oleg","family":"Yarishkin","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, San Diego, CA, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3489-1799","authenticated-orcid":true,"given":"Renhao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, San Diego, CA, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8407-6859","authenticated-orcid":true,"given":"Saba Heydari","family":"Seradj","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, San Diego, CA, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3762-7046","authenticated-orcid":true,"given":"Verina H.","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, San Diego, CA, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1327-5789","authenticated-orcid":true,"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, San Diego, CA, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7452-9260","authenticated-orcid":true,"given":"M. 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