{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:55:45Z","timestamp":1792266945865,"version":"4.4.0"},"reference-count":115,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6815","funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE-2034835"],"award-info":[{"award-number":["DGE-2034835"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH132689"],"award-info":[{"award-number":["R01MH132689"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00NS111731"],"award-info":[{"award-number":["R00NS111731"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1MH130991"],"award-info":[{"award-number":["UM1MH130991"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RM1MH132651"],"award-info":[{"award-number":["RM1MH132651"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 NS048004"],"award-info":[{"award-number":["T32 NS048004"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["Young Investigator Award"],"award-info":[{"award-number":["Young Investigator Award"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000879","name":"Alfred P. Sloan Foundation","doi-asserted-by":"publisher","award":["Sloan Neuroscience Fellowship"],"award-info":[{"award-number":["Sloan Neuroscience Fellowship"]}],"id":[{"id":"10.13039\/100000879","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015591","name":"Rose Hills Foundation","doi-asserted-by":"publisher","award":["Innovation Award"],"award-info":[{"award-number":["Innovation Award"]}],"id":[{"id":"10.13039\/100015591","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001207","name":"Esther A. and Joseph Klingenstein Fund","doi-asserted-by":"publisher","award":["Klingenstein-Simons Fellowship"],"award-info":[{"award-number":["Klingenstein-Simons Fellowship"]}],"id":[{"id":"10.13039\/100001207","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008623","name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008623","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015591","name":"Rose Hills Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015591","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wendy Ablon Trust","award":["Ablon Scholar Award"],"award-info":[{"award-number":["Ablon Scholar Award"]}]},{"DOI":"10.13039\/100008623","name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles","doi-asserted-by":"publisher","award":["UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research Training Program"],"award-info":[{"award-number":["UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research Training Program"]}],"id":[{"id":"10.13039\/100008623","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005931","name":"International Foundation for Ethical Research","doi-asserted-by":"publisher","award":["IFER Graduate Fellowship for the Alternative Use of Animals in Science"],"award-info":[{"award-number":["IFER Graduate Fellowship for the Alternative Use of Animals in Science"]}],"id":[{"id":"10.13039\/100005931","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2026,9,3]]},"abstract":"<jats:p>\n                    The human cerebral cortex develops through coordinated signals from within the cortex and from other brain regions, including the thalamus. However, how thalamic neuronal projections influence early human cortical development remains less well-understood. In this study, we fused cortical and thalamic organoids to investigate how thalamic input shapes the maturation of human cortical cells. Using single-nuclei RNA-sequencing and cellular imaging, we found that thalamic input increases the production of cortical excitatory neurons. We identify neurexin-1 (NRXN1) as a mediator of physical contact between thalamic axons and cortical outer radial glia. Genetic knockout of thalamic\n                    <jats:italic toggle=\"yes\">NRXN1<\/jats:italic>\n                    reduced these contacts and attenuated the production of upper-layer excitatory neurons. These findings reveal a mechanism by which thalamic input regulates human cortical progenitors and shapes excitatory neuron production during development.\n                  <\/jats:p>","DOI":"10.1126\/science.ady5180","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:00:43Z","timestamp":1788458443000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Thalamic NRXN1-mediated input to human cortical progenitors drives excitatory neurogenesis"],"prefix":"10.1126","volume":"393","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4796-6182","authenticated-orcid":true,"given":"Claudia V.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4293-6002","authenticated-orcid":true,"given":"Antoni","family":"Martija","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6966-5632","authenticated-orcid":true,"given":"Daniel C.","family":"Jaklic","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3047-6897","authenticated-orcid":true,"given":"Rista","family":"White","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5788-3092","authenticated-orcid":true,"given":"Marty G.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5507-2656","authenticated-orcid":true,"given":"Patricia R.","family":"Nano","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2246-8961","authenticated-orcid":true,"given":"Jose A.","family":"Soto","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3040-0211","authenticated-orcid":true,"given":"Jessenya","family":"Mil","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0932-1761","authenticated-orcid":true,"given":"Dakshesh","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0399-9481","authenticated-orcid":true,"given":"Hunter E.","family":"Schweiger","sequence":"additional","affiliation":[{"name":"Genomics Institute, University of California Santa Cruz, Santa Cruz, CA, USA."},{"name":"Department of Molecular, Cellular and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Genomics Institute, University of California Santa Cruz, Santa Cruz, CA, USA."},{"name":"Department of Electrical and Computer Engineering, University of California Santa Cruz, Santa Cruz, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Fazzari","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Michigan, Ann Arbor, MI, USA."},{"name":"Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2972-1528","authenticated-orcid":true,"given":"Jack M.","family":"Parent","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Michigan, Ann Arbor, MI, USA."},{"name":"Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA."},{"name":"VA Ann Arbor Healthcare System, Ann Arbor, MI, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1634-7514","authenticated-orcid":true,"given":"Mohammed A.","family":"Mostajo-Radji","sequence":"additional","affiliation":[{"name":"Genomics Institute, University of California Santa Cruz, Santa Cruz, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2896-3450","authenticated-orcid":true,"given":"Daniel H.","family":"Geschwind","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA."},{"name":"Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA."},{"name":"Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4625-6899","authenticated-orcid":true,"given":"Aparna","family":"Bhaduri","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1990.055.01.048"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-04-01194.1992"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/2.4.336"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13185"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2018.04.018"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav7617"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5786-12.2013"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.20770"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.67549"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2201355119"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.06.030"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00424"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.12.060"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08845"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-023-00675-z"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1977.0040"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/12.1.37"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhy327"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.12.015"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.09.002"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1315710110"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2026.07.023"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-1962-0"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.09.010"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05219-6"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.01.017"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1289-x"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2019.100001"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00211-2"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.036"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.12.028"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20284"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01472-2"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.12.012"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu156"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq219"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2506573122"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.104927"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.06.011"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202407137"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09033-8"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.05.024"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.166074"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs137"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn195"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-01-00201.2001"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0293-12.2012"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0601-15.2015"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3415"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22047"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap8809"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25980"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1506-7"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-021-00802-y"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05277-w"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.07.039"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-025-01933-2"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade9516"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13390"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.15.2923"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.58737"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0744-4"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-019-0247-2"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04230-7"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21246-9"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890020110"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.31659"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.08.016"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80877-6"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1074"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.11.035"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.12.012"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.11.034"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24638"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.06.005"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.12.019"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03910-8"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1994.tb00565.x"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00193411"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800003266"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.11.045"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21635"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1177\/1535759720959320"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1515\/bjmg-2016-0031"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39420-6"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.06.014"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1538-11.2012"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07456"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2007.01.011"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0348-14.2014"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-202242"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059685"},{"key":"e_1_3_2_94_2","first-page":"216","article-title":"Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex","volume":"27","author":"Harkin L. F.","year":"2017","unstructured":"L. F. Harkin, S. J. Lindsay, Y. Xu, A. Alzu\u2019bi, A. Ferrara, E. A. Gullon, O. G. James, G. J. Clowry, Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex. Cereb. Cortex 27, 216\u2013232 (2017). 28013231","journal-title":"Cereb. Cortex"},{"key":"e_1_3_2_95_2","first-page":"115","article-title":"Neurexin-1\u03b1 regulates neurite growth of rat hippocampal neurons","volume":"11","author":"Wang A.","year":"2019","unstructured":"A. Wang, Y. Y. Xiang, B. B. Yang, W. Y. Lu, Neurexin-1\u03b1 regulates neurite growth of rat hippocampal neurons. Int. J. Physiol. Pathophysiol. Pharmacol. 11, 115\u2013125 (2019). 31523359","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0664-z"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.1050"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.299081"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03625-y"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2021.03.015"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.64"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1726"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00033"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23175-z"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-023-01943-7"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2019.03.003"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.adf9941"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-01767-y"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.07.054"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.90"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-128"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.adf6812"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022111118"},{"key":"e_1_3_2_114_2","doi-asserted-by":"crossref","unstructured":"E. Fazzari D. J. Azizad M. X. Li W. Ge S. Baisiwala D. Cadet P. R. Nano R. L. Kan T. Perryman H. A. Tum C. Tse B. Wick C. V. Arguelles K. S. Patel L. M. Liau R. M. Prins D. A. Nathanson A. Bhaduri Predictable clonal hierarchies from restricted progenitors provide a framework for cell type-specific therapies in glioblastoma. bioRxiv 2026.02.21.707071 [Preprint] (2026). https:\/\/doi.org\/10.64898\/2026.02.21.707071.","DOI":"10.64898\/2026.02.21.707071"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114862"},{"key":"e_1_3_2_116_2","doi-asserted-by":"crossref","unstructured":"M. Pachitariu N. Steinmetz S. Kadir M. Carandini K. D. Harris Kilosort: Realtime spike-sorting for extracellular electrophysiology with hundreds of channels. bioRxiv 061481 [Preprint] (2016). https:\/\/doi.org\/10.1101\/061481.","DOI":"10.1101\/061481"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.ady5180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:01:34Z","timestamp":1788458494000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.ady5180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":115,"journal-issue":{"issue":"6815","published-print":{"date-parts":[[2026,9,3]]}},"alternative-id":["10.1126\/science.ady5180"],"URL":"https:\/\/doi.org\/10.1126\/science.ady5180","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]},"assertion":[{"value":"2025-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eady5180"}}