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In this work, we show that Ms4a7 is up-regulated in cDC1s after tumor antigen uptake or exposure to exogenous stimuli and is required for their cross-priming ability. Although\n                    <jats:italic toggle=\"yes\">Ms4a7<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice showed normal cDC1 development and turnover, they failed to prime antigen-specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells following infection or tumor development. In human cancers,\n                    <jats:italic toggle=\"yes\">MS4A7<\/jats:italic>\n                    was expressed in a subset of cDC1s, preferentially enriched in dLNs, and correlated with patient survival. Our findings suggest a critical role for Ms4a7 in cDC1-mediated cross-presentation and antitumor CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses.\n                  <\/jats:p>","DOI":"10.1126\/science.ady5362","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T19:02:59Z","timestamp":1763060579000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":15,"title":["Ms4a7 expression in cDC1s determines cross-presentation and antitumor immunity"],"prefix":"10.1126","volume":"390","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2476-0357","authenticated-orcid":true,"given":"Bowen","family":"Xie","sequence":"first","affiliation":[{"name":"Westlake University School of Medicine, Hangzhou, Zhejiang, China."},{"name":"Institute for Immunology and School of Medicine, Tsinghua University, Beijing, China."},{"name":"Tsinghua-Peking Center for Life Sciences, Tsinghua 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