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These waves are initiated by Cad96Ca receptor tyrosine kinase signaling, triggering phospholipase C\u2013\u03b3\u2013mediated calcium release from the endoplasmic reticulum. A cell type\u2013specific \u201cinnexin code\u201d coordinates wave propagation through a defined gap junction network among non-neuronal retinal cells, excluding photoreceptors. Wave intensity scales with ommatidial size, triggering stronger myosin II\u2013driven apical contraction at interommatidial boundaries in larger ommatidia. This size-dependent mechanism compensates for early boundary irregularities, ensuring uniform ommatidial packing that is critical for precise optical architecture. Our findings reveal how synchronized calcium signaling among non-neuronal cells orchestrates tissue patterning in the developing nervous system.\n                  <\/jats:p>","DOI":"10.1126\/science.ady5541","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T19:02:32Z","timestamp":1763665352000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":12,"title":["Retinal calcium waves coordinate uniform tissue patterning of the\n                    <i>Drosophila<\/i>\n                    eye"],"prefix":"10.1126","volume":"390","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9155-8445","authenticated-orcid":true,"given":"Ben Jiwon","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Biology, New York University, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8529-1251","authenticated-orcid":true,"given":"Yen-Chung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biology, New York University, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6914-1413","authenticated-orcid":true,"given":"Claude","family":"Desplan","sequence":"additional","affiliation":[{"name":"Department of Biology, New York University, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.854422"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201506106"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2222"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-071714-033842"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-071013-013941"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3802"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3484"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-092910-154033"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.72435"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.06.026"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.10.026"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.01.008"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2013.11.011"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.030"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","unstructured":"S. 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