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This study identified a circuit for regulating pain rhythmicity that might be targeted to improve chronic pain management.\n                  <\/jats:p>","DOI":"10.1126\/science.ady6455","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T18:01:27Z","timestamp":1773943287000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":4,"title":["Hypothalamic clock governs circadian pain"],"prefix":"10.1126","volume":"391","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7511-1747","authenticated-orcid":true,"given":"Hong-Rui","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, PR 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