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In this work, we investigate the role of mouse beige fat, as a model of human inducible brown fat, in adipocyte-vascular cross-talk. Using adipocyte-specific\n                    <jats:italic toggle=\"yes\">Prdm16<\/jats:italic>\n                    knockout mice with a loss of beige adipocyte identity, we discovered marked remodeling of perivascular adipose tissue, increased vascular reactivity, and elevated blood pressure. We show that the circulating enzyme QSOX1 is derepressed in\n                    <jats:italic toggle=\"yes\">Prdm16<\/jats:italic>\n                    -deficient adipocytes, and deletion of\n                    <jats:italic toggle=\"yes\">Qsox1<\/jats:italic>\n                    in\n                    <jats:italic toggle=\"yes\">Prdm16<\/jats:italic>\n                    conditional knockout mice prevented vascular fibrosis and normalized vascular reactivity. These results demonstrate a key role for beige adipocytes in blood pressure regulation and identify QSOX1 as an important mediator of adipocyte-vascular cross-talk.\n                  <\/jats:p>","DOI":"10.1126\/science.ady8644","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T19:01:57Z","timestamp":1768503717000},"page":"306-313","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":19,"title":["Ablation of\n                    <i>Prdm16<\/i>\n                    and beige fat identity causes vascular remodeling and elevated blood pressure"],"prefix":"10.1126","volume":"391","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1024-4506","authenticated-orcid":true,"given":"Mascha","family":"Koenen","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, 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