{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:37:14Z","timestamp":1792445834363,"version":"4.5.0"},"reference-count":78,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6805","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2026,6,25]]},"abstract":"<jats:p>\n                    Color vision in catarrhine primates relies on red-, green-, and blue-sensitive cone pigments that share an 11-\n                    <jats:italic toggle=\"yes\">cis<\/jats:italic>\n                    -retinal chromophore but differ in absorption maxima. Red and green pigments arose by recent gene duplication and differ at only a few residues. Here, we report cryo\u2013electron microscopy structures of red and green cone pigments from the cynomolgus macaque (\n                    <jats:italic toggle=\"yes\">Macaca fascicularis<\/jats:italic>\n                    ) integrated with low-temperature vibrational spectroscopy and quantum mechanical and molecular mechanical modeling. The red-green spectral shift is dominated by threonine 285, the hydroxyl dipole of which modulates chromophore electrostatics, whereas steric effects appear modest. We also identified membrane-facing lateral openings in cone pigments but not in inactive rhodopsin. Comparisons with active-state structures suggest activation-dependent gating, and mutational and spectroscopic analyses support a role for this opening in retinal uptake and rapid pigment regeneration.\n                  <\/jats:p>","DOI":"10.1126\/science.adz3996","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:00:46Z","timestamp":1782410446000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Structural insights into spectral tuning and retinal exchange in cone visual pigments"],"prefix":"10.1126","volume":"392","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8250-4257","authenticated-orcid":true,"given":"Sayaka","family":"Ohashi","sequence":"first","affiliation":[{"name":"Life Science and Applied Chemistry, Nagoya Institute of Technology, Nagoya, 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