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We found the epigenetic enzyme CARM1 (coactivator-associated arginine methyltransferase 1) to be a selective negative regulator of cancer antigen presentation by cDC1s but not cDC2s. Inactivation of the\n                    <jats:italic toggle=\"yes\">Carm1<\/jats:italic>\n                    gene promoted cDC1 antigen cross-presentation, activation, and accumulation in tumors, and a CARM1 inhibitor enhanced cDC1-mediated priming of T cells by means of a cancer neoantigen vaccine. CARM1 inhibition increased chromatin accessibility at BATF3-Jun and RelA sites that are critical for cDC1 function and activation. Transforming growth factor\u2013\u03b2 regulated\n                    <jats:italic toggle=\"yes\">Carm1<\/jats:italic>\n                    expression, which suggests that CARM1 inactivation enhanced intratumoral cDC1 function without altering cDC1 homeostasis. These studies identify CARM1 as a potential therapeutic target for enhancing the antitumor function of mouse and human cDC1s.\n                  <\/jats:p>","DOI":"10.1126\/science.aea1200","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T18:02:13Z","timestamp":1783620133000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":5,"title":["The CARM1 epigenetic enzyme inhibits cross-presenting dendritic cell function in cancer immunity"],"prefix":"10.1126","volume":"393","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0944-2214","authenticated-orcid":true,"given":"Xixi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA."},{"name":"Department of Immunology, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1970-6554","authenticated-orcid":true,"given":"Sherin","family":"Xirenayi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA."},{"name":"Broad Institute of Harvard and MIT, Cambridge, MA, USA."},{"name":"Systems, Synthetic, and Quantitative Biology Graduate Program, Harvard University, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3941-2486","authenticated-orcid":true,"given":"Ye","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4366-933X","authenticated-orcid":true,"given":"Wen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyang","family":"Han","sequence":"additional","affiliation":[{"name":"Gene Lay Institute of Immunology and Inflammation, Brigham and Women\u2019s Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Sobral","sequence":"additional","affiliation":[{"name":"Harvard John A. 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