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Here, we defined Group 2 innate lymphoid cells (ILC2s) as key regulators of fibroblast homeostasis in the pancreas. ILC2s colocalized with fibroblasts expressing the genes\n                    <jats:italic toggle=\"yes\">\n                      Pi16\n                      <jats:sup>+<\/jats:sup>\n                      Dpp4\n                      <jats:sup>+<\/jats:sup>\n                      Ly6c\n                      <jats:sup>+<\/jats:sup>\n                    <\/jats:italic>\n                    in an interstitial niche of the exocrine pancreas, which encapsulates the organ parenchyma. ILC2s specifically regulated the expansion of\n                    <jats:italic toggle=\"yes\">\n                      Pi16\n                      <jats:sup>+<\/jats:sup>\n                      Dpp4\n                      <jats:sup>+<\/jats:sup>\n                      Ly6c\n                      <jats:sup>+<\/jats:sup>\n                    <\/jats:italic>\n                    fibroblasts, which have progenitor capacity, while restraining differentiated intraparenchymal\n                    <jats:italic toggle=\"yes\">\n                      Col15a1\n                      <jats:sup>+<\/jats:sup>\n                    <\/jats:italic>\n                    fibroblasts during inflammation. These circuits reinforced fibroblast numbers after injury and set an inflammatory threshold. The ILC2 and\n                    <jats:italic toggle=\"yes\">\n                      Pi16\n                      <jats:sup>+<\/jats:sup>\n                      Dpp4\n                      <jats:sup>+<\/jats:sup>\n                      Ly6c\n                      <jats:sup>+<\/jats:sup>\n                    <\/jats:italic>\n                    fibroblast progenitor niche expanded around tumors and controlled cancer-associated fibroblast ontogeny and density. Hence, ILC2-fibroblast dialogue represents a regulatory node that locally orchestrates tissue homeostasis and pathology.\n                  <\/jats:p>","DOI":"10.1126\/science.aea5113","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:04:19Z","timestamp":1783015459000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["ILC2s regulate a fibroblast progenitor niche in the pancreas"],"prefix":"10.1126","volume":"393","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6287-3543","authenticated-orcid":true,"given":"Thomas","family":"Yip","sequence":"first","affiliation":[{"name":"University of Cambridge, CRUK Cambridge Institute, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4911-6891","authenticated-orcid":true,"given":"Julie","family":"Stockis","sequence":"additional","affiliation":[{"name":"University of Cambridge, CRUK Cambridge Institute, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8410-7870","authenticated-orcid":true,"given":"Charlotte","family":"Simpson","sequence":"additional","affiliation":[{"name":"University of Cambridge, CRUK Cambridge Institute, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6354-0915","authenticated-orcid":true,"given":"Erika E.","family":"McCartney","sequence":"additional","affiliation":[{"name":"University of Toronto, Department of Immunology, Toronto, ON, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shwetha","family":"Raghunathan","sequence":"additional","affiliation":[{"name":"University of Cambridge, CRUK Cambridge Institute, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9074-9415","authenticated-orcid":true,"given":"Martha M.","family":"Rangel-Sosa","sequence":"additional","affiliation":[{"name":"University of Cambridge, CRUK Cambridge Institute, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2369-6795","authenticated-orcid":true,"given":"Sydney N.","family":"Hummel","sequence":"additional","affiliation":[{"name":"University of Cambridge, CRUK Cambridge Institute, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1740-9350","authenticated-orcid":true,"given":"Julia","family":"Moreno-Vicente","sequence":"additional","affiliation":[{"name":"University of Cambridge, CRUK Cambridge Institute, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1056-5403","authenticated-orcid":true,"given":"Gianmarco","family":"Raddi","sequence":"additional","affiliation":[{"name":"University of Cambridge, CRUK Cambridge Institute, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Garcia","sequence":"additional","affiliation":[{"name":"University of Cambridge, CRUK Cambridge Institute, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rugile","family":"Linkute","sequence":"additional","affiliation":[{"name":"University of Cambridge, CRUK Cambridge Institute, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9541-3611","authenticated-orcid":true,"given":"Silvain","family":"Pinaud","sequence":"additional","affiliation":[{"name":"University of Cambridge, CRUK Cambridge Institute, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maye F.","family":"Cheng","sequence":"additional","affiliation":[{"name":"University of Toronto, Department of Immunology, Toronto, ON, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6609-1935","authenticated-orcid":true,"given":"Lesley A.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Cellular and Physiological Sciences and Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3048-9102","authenticated-orcid":true,"given":"T. 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