{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:10:24Z","timestamp":1789063824633,"version":"build-2803163510"},"reference-count":73,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6816","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31CA278581"],"award-info":[{"award-number":["F31CA278581"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA228211"],"award-info":[{"award-number":["R01 CA228211"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA228211"],"award-info":[{"award-number":["R01 CA228211"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA216101"],"award-info":[{"award-number":["R01 CA216101"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA285867"],"award-info":[{"award-number":["R01 CA285867"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 AI151562"],"award-info":[{"award-number":["R21 AI151562"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32GM133351"],"award-info":[{"award-number":["T32GM133351"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F30HL178290"],"award-info":[{"award-number":["F30HL178290"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000884","name":"Cancer Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000884","name":"Cancer Research Institute","doi-asserted-by":"publisher","award":["CRI4122"],"award-info":[{"award-number":["CRI4122"]}],"id":[{"id":"10.13039\/100000884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007911","name":"University of California, San Diego","doi-asserted-by":"publisher","award":["014839"],"award-info":[{"award-number":["014839"]}],"id":[{"id":"10.13039\/100007911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002387","name":"National Cancer Institute, Cairo University","doi-asserted-by":"publisher","award":["P30 CA01495"],"award-info":[{"award-number":["P30 CA01495"]}],"id":[{"id":"10.13039\/501100002387","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018259","name":"Salk Institute for Biological Studies","doi-asserted-by":"publisher","award":["014838"],"award-info":[{"award-number":["014838"]}],"id":[{"id":"10.13039\/100018259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018259","name":"Salk Institute for Biological Studies","doi-asserted-by":"publisher","award":["NIH-NCI CCSG P30 CA014195"],"award-info":[{"award-number":["NIH-NCI CCSG P30 CA014195"]}],"id":[{"id":"10.13039\/100018259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023864","name":"NHS Innovation Accelerator","doi-asserted-by":"publisher","award":["P30 AG068635"],"award-info":[{"award-number":["P30 AG068635"]}],"id":[{"id":"10.13039\/501100023864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018259","name":"Salk Institute for Biological Studies","doi-asserted-by":"publisher","award":["014842"],"award-info":[{"award-number":["014842"]}],"id":[{"id":"10.13039\/100018259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018259","name":"Salk Institute for Biological Studies","doi-asserted-by":"publisher","award":["014846"],"award-info":[{"award-number":["014846"]}],"id":[{"id":"10.13039\/100018259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018259","name":"Salk Institute for Biological Studies","doi-asserted-by":"publisher","award":["NIH-NCI CCSG P30 CA014195"],"award-info":[{"award-number":["NIH-NCI CCSG P30 CA014195"]}],"id":[{"id":"10.13039\/100018259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023864","name":"NHS Innovation Accelerator","doi-asserted-by":"publisher","award":["P30 AG068635"],"award-info":[{"award-number":["P30 AG068635"]}],"id":[{"id":"10.13039\/501100023864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023864","name":"NHS Innovation Accelerator","doi-asserted-by":"publisher","award":["P01 AG073084-04"],"award-info":[{"award-number":["P01 AG073084-04"]}],"id":[{"id":"10.13039\/501100023864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018259","name":"Salk Institute for Biological Studies","doi-asserted-by":"publisher","award":["026396"],"award-info":[{"award-number":["026396"]}],"id":[{"id":"10.13039\/100018259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018259","name":"Salk Institute for Biological Studies","doi-asserted-by":"publisher","award":["NIH-NCI CCSG P30 CA014195"],"award-info":[{"award-number":["NIH-NCI CCSG P30 CA014195"]}],"id":[{"id":"10.13039\/100018259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023864","name":"NHS Innovation Accelerator","doi-asserted-by":"publisher","award":["P30 AG068635"],"award-info":[{"award-number":["P30 AG068635"]}],"id":[{"id":"10.13039\/501100023864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001642","name":"Glenn Foundation for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001642","name":"Glenn Foundation for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008746","name":"National Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008746","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017427","name":"George E. Hewitt Foundation for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017427","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000884","name":"Cancer Research Institute","doi-asserted-by":"publisher","award":["T32CA009370-39"],"award-info":[{"award-number":["T32CA009370-39"]}],"id":[{"id":"10.13039\/100000884","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2026,9,10]]},"abstract":"<jats:p>\n                    Interferons (IFNs) are proinflammatory cytokines that promote immune cell engagement to eliminate malignant cells. Paradoxically, chronic interferon signaling can also activate anti-inflammatory mechanisms that allow cancer cells to evade the immune system. In this study, we sought to determine the cellular mechanisms underlying this switch from antitumorigenic to protumorigenic interferon activity. We show that chronic type II interferon (IFN-II) exposure distinctively induced tumor growth by activating a type I interferon (IFN-I) response mediated by release of double-stranded mitochondrial RNA (ds-mtRNA) into the cytoplasm. This IFN-I signal synergized with IFN-II to enhance tumor growth by increasing immunosuppressive prostaglandin E\n                    <jats:sub>2<\/jats:sub>\n                    (PGE\n                    <jats:sub>2<\/jats:sub>\n                    ) synthesis through increased cyclooxygenase 2 expression. Elimination of PGE\n                    <jats:sub>2<\/jats:sub>\n                    synthesis in immunotherapy-resistant melanoma cells restored their responsiveness to anti-PD1 treatment, indicating that this covert mtRNA-IFN-prostaglandin pathway could be a therapeutic target to combat immunotherapy resistance.\n                  <\/jats:p>","DOI":"10.1126\/science.aec0002","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:00:33Z","timestamp":1789063233000},"page":"1107-1116","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Chronic type II interferon promotes tumor growth through mitochondrial RNA\u2013induced type I interferon and prostaglandin synthesis"],"prefix":"10.1126","volume":"393","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6913-6059","authenticated-orcid":true,"given":"Melissa A.","family":"Johnson","sequence":"first","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."},{"name":"Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5797-2984","authenticated-orcid":true,"given":"Siva Karthik","family":"Varanasi","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7412-3095","authenticated-orcid":true,"given":"Kailash Chandra","family":"Mangalhara","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Lande","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."},{"name":"Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8942-7037","authenticated-orcid":true,"given":"Gladys R.","family":"Rojas","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9034-1121","authenticated-orcid":true,"given":"Pau B.","family":"Esparza-Molt\u00f3","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8445-3749","authenticated-orcid":true,"given":"Mack B.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9965-3962","authenticated-orcid":true,"given":"Neva","family":"Olliffe","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."},{"name":"Biological Sciences Graduate Program, University of California San Diego, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4136-8771","authenticated-orcid":true,"given":"Karl","family":"Wessendorf-Rodriguez","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2883-7008","authenticated-orcid":true,"given":"Sagnika","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5156-6635","authenticated-orcid":true,"given":"Dan","family":"Chen","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3912-3660","authenticated-orcid":true,"given":"Alexandra G.","family":"Moyzis","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4667-8808","authenticated-orcid":true,"given":"Matthew P.","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."},{"name":"Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA, USA."},{"name":"Medical Science Training Program, University of California San Diego School of Medicine, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2768-8058","authenticated-orcid":true,"given":"Rebecca","family":"Chinn","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."},{"name":"Department of Bioengineering, University of California San Diego, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1270-135X","authenticated-orcid":true,"given":"Ziyan","family":"Xu","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6527-7508","authenticated-orcid":true,"given":"Kym J.","family":"Grae","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0191-4165","authenticated-orcid":true,"given":"Victoria","family":"Tripple","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0461-5614","authenticated-orcid":true,"given":"Michael A.","family":"LaPorta","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2404-3040","authenticated-orcid":true,"given":"Christian M.","family":"Metallo","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3724-3826","authenticated-orcid":true,"given":"Diana C.","family":"Hargreaves","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1674-1420","authenticated-orcid":true,"given":"Susan M.","family":"Kaech","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."},{"name":"NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2899-8717","authenticated-orcid":true,"given":"Gerald S.","family":"Shadel","sequence":"additional","affiliation":[{"name":"Salk Institute for Biological Studies, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00658-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13051037"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-1059"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1961"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-virology-092818-015756"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02061"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2018.0087"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.019"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.11.022"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-022-00490-y"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12498"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq1053"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.08.012"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-025-06628-7"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7519-8_16"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.06.041"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01489"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.70360"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19287-7"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-032620-104401"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111774"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-01121-x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201949799"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03048-z"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14156"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-024-01145-1"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00443-w"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.015"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2809"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12591"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-23-2627"},{"key":"e_1_3_2_33_2","first-page":"303","article-title":"Expression of cyclooxygenase 2 in human malignant melanoma","volume":"61","author":"Denkert C.","year":"2001","unstructured":"C. Denkert, M. K\u00f6bel, S. Berger, A. Siegert, A. Leclere, U. Trefzer, S. Hauptmann, Expression of cyclooxygenase 2 in human malignant melanoma. Cancer Res. 61, 303\u2013308 (2001). 11196178","journal-title":"Cancer Res."},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29606-9"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-024-00720-w"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.4161\/2162402X.2014.988460"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v5.i4.677"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.3390\/biology9120434"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08257-4"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.015"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3831"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.10.020"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07352-w"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1612920114"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07254-x"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05720-6"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03269-w"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.744284"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav4011"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005466"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/celldisc.2016.24"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.10.018"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2024.104610"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-022-00462-5"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade8520"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.adf1329"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2022.102021"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.017"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.05.004"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4396"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.05.005"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.21856"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.14806\/ej.17.1.200"},{"key":"e_1_3_2_66_2","unstructured":"J. A. E. 1 R. A. Edwards R. Edwards Fastq-pair: efficient synchronization of paired-end fastq files. bioRxiv 552885 (2019)."},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-021-04344-9"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2014.07.006"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2011.07.006"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep27688"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.05.003"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-022-00490-y"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aec0002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:00:44Z","timestamp":1789063244000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aec0002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":73,"journal-issue":{"issue":"6816","published-print":{"date-parts":[[2026,9,10]]}},"alternative-id":["10.1126\/science.aec0002"],"URL":"https:\/\/doi.org\/10.1126\/science.aec0002","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]},"assertion":[{"value":"2025-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-08","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}