{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:22:56Z","timestamp":1788459776929,"version":"build-2803163510"},"reference-count":74,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6815","funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030899","name":"Daewoong Foundation","doi-asserted-by":"publisher","award":["031B1230A"],"award-info":[{"award-number":["031B1230A"]}],"id":[{"id":"10.13039\/100030899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/Y002997\/1"],"award-info":[{"award-number":["BB\/Y002997\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gatsby Charitable Foundation CZ"},{"DOI":"10.13039\/501100006447","name":"Universit\u00e4t Z\u00fcrich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004189","name":"Max-Planck-Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ecole Normale Superieure de Lyon"},{"name":"Lyon BL"},{"name":"Gatsby Charitable Foundation CZ TN"}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2026,9,3]]},"abstract":"<jats:p>Angiosperm seed formation requires the coordinated development of the products of double fertilization\u2014the embryo and the endosperm. The endosperm mediates efficient nutrient transfer from surrounding maternal tissues to the developing embryo. This function requires a polarized tissue organization, which manifests as early polar gene expression and polar cellularization dynamics. We show that the receptor kinase HAIKU2 (IKU2) acts in coordination with the transcription factor WRKY10\/MINISEED3 (MINI3) to ensure robust endosperm polarity establishment through the activity of the homeodomain transcription factors WUSCHEL-RELATED HOMEOBOX 8 (WOX8) and WOX9. This process depends on egg cell fertilization and is mediated through the peptide PATHOGEN-INDUCED PEPTIDE\u2013LIKE 7 (PIPL7), which acts as a potential IKU2 ligand. Our results reveal how a molecular paracrine dialog between the embryo and endosperm ensures optimal seed developmental coordination.<\/jats:p>","DOI":"10.1126\/science.aed6035","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:00:43Z","timestamp":1788458443000},"page":"1002-1008","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["An embryo-derived peptide signal directs endosperm polarity in\n                    <i>Arabidopsis<\/i>"],"prefix":"10.1126","volume":"393","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7736-5882","authenticated-orcid":true,"given":"Audrey","family":"Creff","sequence":"first","affiliation":[{"name":"Laboratoire Reproduction et D\u00e9veloppement des Plantes, ENS de Lyon, CNRS, INRAE, UCB Lyon, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3953-1648","authenticated-orcid":true,"given":"Jack","family":"Rhodes","sequence":"additional","affiliation":[{"name":"The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0743-594X","authenticated-orcid":true,"given":"Camille","family":"Sala\u00fcn","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Molecular Plant Physiology, Potsdam, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Larive","sequence":"additional","affiliation":[{"name":"Laboratoire Reproduction et D\u00e9veloppement des Plantes, ENS de Lyon, CNRS, INRAE, UCB Lyon, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3747-9604","authenticated-orcid":true,"given":"Vincent","family":"Bayle","sequence":"additional","affiliation":[{"name":"Laboratoire Reproduction et D\u00e9veloppement des Plantes, ENS de Lyon, CNRS, INRAE, UCB Lyon, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6801-2750","authenticated-orcid":true,"given":"Maialen","family":"Garmendia-Calvo","sequence":"additional","affiliation":[{"name":"The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5664-9090","authenticated-orcid":true,"given":"Emma","family":"Turley","sequence":"additional","affiliation":[{"name":"The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1773-3361","authenticated-orcid":true,"given":"Tatsuya","family":"Nobori","sequence":"additional","affiliation":[{"name":"The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7990-3592","authenticated-orcid":true,"given":"Duarte D.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Molecular Plant Physiology, Potsdam, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2371-9996","authenticated-orcid":true,"given":"Benoit","family":"Landrein","sequence":"additional","affiliation":[{"name":"Laboratoire Reproduction et D\u00e9veloppement des Plantes, ENS de Lyon, CNRS, INRAE, UCB Lyon, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4935-8583","authenticated-orcid":true,"given":"Cyril","family":"Zipfel","sequence":"additional","affiliation":[{"name":"The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK."},{"name":"Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Z\u00fcrich, Z\u00fcrich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1425-9545","authenticated-orcid":true,"given":"Gwyneth","family":"Ingram","sequence":"additional","affiliation":[{"name":"Laboratoire Reproduction et D\u00e9veloppement des Plantes, ENS de Lyon, CNRS, INRAE, UCB Lyon, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.137190"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7382"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35542-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.104.027136"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004970050169"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.077057"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00152"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2021.102121"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41477-021-00922-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.107.055137"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508418102"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41477-020-0749-5"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2013.11.008"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/95.4.929"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/plcell\/koab007"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.14570"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2021.640346"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1305175110"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/jipb.70266"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2008.03.008"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00963"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.111.094839"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.292409.116"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.01.009"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1167784"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.08.033"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)01067-5"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1222061110"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.201184"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.12.079"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.07.019"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1882810"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.11.3.407"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.11.5319"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/plcell\/koab173"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.74687"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/nph.18827"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msad220"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msaf294"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004331"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/plcell\/koab292"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/nph.17919"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-55194-x"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.11.031"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41477-025-02072-z"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.204449"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41477-026-02295-8"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1714972115"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5475.2360"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.adx2508"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80265-8"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022110741"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.110.171249"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.110.171249"},{"key":"e_1_3_2_56_2","unstructured":"RDP_Vince RDP-vbayle\/MacroScripsCreff2026: MacroScripsCreff2026 (Version MacroScripsCreff2026) [Computer software] Zenodo (2026)."},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.102.018762"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002126"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.03.013"},{"key":"e_1_3_2_60_2","first-page":"748","article-title":"A rapid CTAB DNA isolation technique useful for RAPD fingerprinting and other PCR applications","volume":"14","author":"Stewart C. N.","year":"1993","unstructured":"C. N. Stewart Jr., L. E. Via, A rapid CTAB DNA isolation technique useful for RAPD fingerprinting and other PCR applications. Biotechniques 14, 748\u2013750 (1993). 8512694","journal-title":"Biotechniques"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2005.01.008"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1186\/1746-4811-2-16"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1021\/sb4001504"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.16.00310"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1619078114"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz365"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204778"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xplc.2020.100135"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.13784"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00497-022-00453-4"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/352524a0"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-3511-7_2"},{"key":"e_1_3_2_74_2","doi-asserted-by":"crossref","unstructured":"J. Hallgren K. D. Tsirigos M. D. Pedersen J. J. A. Armenteros P. Marcatili H. Nielsen A. Krogh O. Winther DeepTMHMM predicts alpha and beta transmembrane proteins using deep neural networks. bioRxiv 2022.04.08.487609 [Preprint] (2022).10.1101\/2022.04.08.487609","DOI":"10.1101\/2022.04.08.487609"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3943"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aed6035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:01:37Z","timestamp":1788458497000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aed6035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":74,"journal-issue":{"issue":"6815","published-print":{"date-parts":[[2026,9,3]]}},"alternative-id":["10.1126\/science.aed6035"],"URL":"https:\/\/doi.org\/10.1126\/science.aed6035","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]},"assertion":[{"value":"2025-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}