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In this work, we mapped 649 variables to children\u2019s brains and compared the resultant BWAS maps with each other and with neurobiological reference patterns. Socioeconomic status (SES) showed the strongest brain-wide associations. The SES associations were strongest in motor and sensory but not cognitive regions, a pattern shared across many BWAS maps, including intelligence quotient (IQ). A single, common BWAS brain pattern existed across variables that was most reflective of a child\u2019s socioeconomics. Adjusting for SES weakened brain-IQ associations, eliminating the BWAS motor and sensory pattern. Brain-with-IQ associations also did not generalize when trained on higher-SES subsamples. Thus, children\u2019s brains vary the most with SES, potentially through SES-dependent sleep deprivation and stress.<\/jats:p>","DOI":"10.1126\/science.aee6213","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T18:01:19Z","timestamp":1781200879000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":16,"title":["Patterns of brain-wide associations reflect socioeconomics"],"prefix":"10.1126","volume":"392","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0032-9052","authenticated-orcid":true,"given":"Scott","family":"Marek","sequence":"first","affiliation":[{"name":"Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA."},{"name":"Allied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA."},{"name":"Neuroimaging Labs Research Center, Washington University School of Medicine, St. Louis, MO, 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