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Balanced energy-protein (BEP) supplements or nicotinamide given to lactating mothers increased milk B-vitamins, while macronutrients, oligosaccharides, bioactive proteins, and microbiome composition were physiologically buffered. Metabolomic and proteomic analyses revealed shifts in vitamin-related metabolites, triglyceride profiles, and intracellular protein representation. In a MISAME-III subset, maternal and infant blood showed concordant changes. Postnatal BEP improved infant growth only in the more undernourished cohort. Improved milk micronutrient quality across settings supports extending maternal supplementation into lactation.<\/jats:p>","DOI":"10.1126\/science.aee9284","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:49:57Z","timestamp":1791485397000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Nutritional interventions\u2019 impacts on human milk: Three trials in low-resource settings"],"prefix":"10.1126","author":[{"given":"Trenton","family":"Dailey-Chwalib\u00f3g","sequence":"first","affiliation":[{"name":"Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium."},{"name":"Agence de Formation de Recherche et d\u2019Expertise en Sant\u00e9 pour l\u2019Afrique (AFRICSant\u00e9), BP, Bobo-Dioulasso, Burkina 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