{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:59:07Z","timestamp":1790276347771,"version":"4.1.0"},"reference-count":70,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6818","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270445"],"award-info":[{"award-number":["32270445"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2026,9,24]]},"abstract":"<jats:p>\n                    Transposable elements mobilize within and occasionally between genomes, including from host to virus. We identified two insertions of the human\n                    <jats:italic toggle=\"yes\">BC200<\/jats:italic>\n                    noncoding RNA gene in the poxvirus molluscum contagiosum virus (MCV), which were likely acquired through long interspersed nuclear element 1 (LINE-1 or L1)\u2013mediated retrotransposition during modern human history. Although\n                    <jats:italic toggle=\"yes\">BC200<\/jats:italic>\n                    was co-opted approximately 40 million years ago to regulate neuronal translation, we show that it never lost its mobilization capacity. Rather,\n                    <jats:italic toggle=\"yes\">BC200<\/jats:italic>\n                    functioned as a \u201cmaster\u201d source of L1-mediated germline retrotransposition events throughout anthropoid evolution, spawning hundreds of lineage-specific insertions. Additionally,\n                    <jats:italic toggle=\"yes\">BC200<\/jats:italic>\n                    has produced insertion polymorphisms segregating in the human population, including individual-specific insertions indicative of ongoing transposition activity. Thus,\n                    <jats:italic toggle=\"yes\">BC200<\/jats:italic>\n                    blurs the line between gene and transposon, combining stable function with persistent mobilization, including a recent escape into a human poxvirus.\n                  <\/jats:p>","DOI":"10.1126\/science.aeh3441","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:00:41Z","timestamp":1790272841000},"page":"1342-1346","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Escape of the\n                    <i>BC200<\/i>\n                    gene to a human poxvirus reveals its persistent transposition in primates"],"prefix":"10.1126","volume":"393","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2742-1641","authenticated-orcid":true,"given":"Pu","family":"Gao","sequence":"first","affiliation":[{"name":"College of Life Sciences, Capital Normal University, Beijing, 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