{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:36:21Z","timestamp":1791228981342,"version":"4.1.0"},"reference-count":73,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2016,9,16]]},"abstract":"<jats:p>\n            A secreted bacterial protein protects worms and mice from\n            <jats:italic>Salmonella<\/jats:italic>\n            pathogenesis.\n          <\/jats:p>","DOI":"10.1126\/sciimmunol.aai7732","type":"journal-article","created":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T19:48:25Z","timestamp":1474660105000},"source":"Crossref","is-referenced-by-count":106,"title":["Exploiting a host-commensal interaction to promote intestinal barrier function and enteric pathogen tolerance"],"prefix":"10.1126","volume":"1","author":[{"given":"Virginia A.","family":"Pedicord","sequence":"first","affiliation":[{"name":"Laboratory of Mucosal Immunology, Rockefeller University, New York, NY 10065, USA."},{"name":"Laboratory of Chemical Biology and Microbial Pathogenesis, Rockefeller University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainsley A. K.","family":"Lockhart","sequence":"additional","affiliation":[{"name":"Laboratory of Mucosal Immunology, Rockefeller University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavita J.","family":"Rangan","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biology and Microbial Pathogenesis, Rockefeller University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Craig","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Loschko","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneta","family":"Rogoz","sequence":"additional","affiliation":[{"name":"Laboratory of Mucosal Immunology, Rockefeller University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard C.","family":"Hang","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biology and Microbial Pathogenesis, Rockefeller University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Mucida","sequence":"additional","affiliation":[{"name":"Laboratory of Mucosal Immunology, Rockefeller University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002533"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101322"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.01.003"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.035"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.11.024"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0314"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2710"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2515"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07008"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-074937"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-091313-103456"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13828"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241165"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12331"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09646"},{"key":"e_1_3_2_17_2","unstructured":"F. Lebreton R. J. L. Willems M. S. Gilmore in Enterococci : From Commensals to Leading Causes of Drug Resistant Infection M. S. Gilmore D. B. Clewell Y. Ike N. Shankar Eds. (Massachusetts Eye and Ear Infirmary 2014)."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2011.08.014"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/319994"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.5.2839-2858.2003"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00762.x"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00077-09"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.12.028"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2011.11.002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07250"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01104-10"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.10.010"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.023"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.109"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209791"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020749"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2010.01511.x"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00919-12"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.02127-12"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90510-X"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005530"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2707"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02045-14"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.168443"},{"key":"e_1_3_2_40_2","first-page":"93","article-title":"Molecular mechanisms of Salmonella virulence and host resistance","volume":"337","author":"Valdez Y.","year":"2009","unstructured":"Y. Valdez, R. B. R. Ferreira, B. B. Finlay, Molecular mechanisms of Salmonella virulence and host resistance. Curr. Top. Microbiol. Immunol. 337, 93\u2013127 (2009).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104911"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.015"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22848"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf3552"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.9.5033-5041.2003"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1086\/498871"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00153-10"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1186\/1757-4749-1-19"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.3920\/BM2009.0012"},{"key":"e_1_3_2_50_2","first-page":"287","article-title":"Clostridium difficile infection","volume":"373","author":"Leffler D. A.","year":"2015","unstructured":"D. A. Leffler, J. T. Lamont, Clostridium difficile infection. N. Engl. J. Med. 373, 287\u2013288 (2015).","journal-title":"N. Engl. J. Med."},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-111212-133343"},{"key":"e_1_3_2_52_2","first-page":"1","article-title":"Role of the innate immune system and host\u2013commensal mutualism","volume":"308","author":"Rakoff-Nahoum S.","year":"2006","unstructured":"S. Rakoff-Nahoum, R. Medzhitov, Role of the innate immune system and host\u2013commensal mutualism. Curr. Top. Microbiol. Immunol. 308, 1\u201318 (2006).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.399998"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909449107"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069901"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182858477"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2014.09.005"},{"key":"e_1_3_2_58_2","first-page":"941","article-title":"Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR\/PKC\/Ras\/ERK\/CREB, PI3K\/Akt\/I\u03baB\/NF-\u03baB and p38\/MSK1\/CREB pathways and negative JNK\/c-Jun\/AP-1 pathway","volume":"36","author":"Lee H. Y.","year":"2010","unstructured":"H. Y. Lee, S. Crawley, R. Hokari, S. Kwon, Y. S. Kim, Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR\/PKC\/Ras\/ERK\/CREB, PI3K\/Akt\/I\u03baB\/NF-\u03baB and p38\/MSK1\/CREB pathways and negative JNK\/c-Jun\/AP-1 pathway. Int. J. Oncol. 36, 941\u2013953 (2010).","journal-title":"Int. J. Oncol."},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006451107"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-092412-155715"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00685-07"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12447"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222195"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2008.04.012"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3535"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408913"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics4040411"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61218-0"},{"key":"e_1_3_2_69_2","first-page":"Unit9A.1","article-title":"Laboratory maintenance of Clostridium difficile","volume":"9","author":"Sorg J. A.","year":"2009","unstructured":"J. A. Sorg, S. S. Dineen, Laboratory maintenance of Clostridium difficile. Curr. Protoc. Microbiol. Chapter 9, Unit9A.1 (2009).","journal-title":"Curr. Protoc. Microbiol."},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-148-11-3651"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.7.3380-3389.2005"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-008-9345-z"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00520-11"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1186\/2049-1891-4-5"}],"container-title":["Science Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciimmunol.aai7732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:48:33Z","timestamp":1705409313000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.aai7732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,16]]},"references-count":73,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9,16]]}},"alternative-id":["10.1126\/sciimmunol.aai7732"],"URL":"https:\/\/doi.org\/10.1126\/sciimmunol.aai7732","relation":{},"ISSN":["2470-9468"],"issn-type":[{"value":"2470-9468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,16]]}}}