{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:11:00Z","timestamp":1790802660176,"version":"4.1.0"},"reference-count":64,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"34","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI-086037"],"award-info":[{"award-number":["AI-086037"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI-061093"],"award-info":[{"award-number":["AI-061093"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K23AI115001"],"award-info":[{"award-number":["K23AI115001"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["1S10RR026992-0110"],"award-info":[{"award-number":["1S10RR026992-0110"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001245","name":"Jeffrey Modell Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007491","name":"Donald E. and Delia B. Baxter Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","award":["KAW 2014.0412"],"award-info":[{"award-number":["KAW 2014.0412"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Henry Gustav Floren Trust","award":["R01 AI125197"],"award-info":[{"award-number":["R01 AI125197"]}]},{"name":"Stanford\u2019s Autoimmunity Center of Excellence","award":["U19-AI110491"],"award-info":[{"award-number":["U19-AI110491"]}]},{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2019,4,12]]},"abstract":"<jats:p>T cells and their proper AIRE-dependent selection prevent the accumulation of autoreactive na\u00efve B cells in the periphery.<\/jats:p>","DOI":"10.1126\/sciimmunol.aav6778","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T19:09:12Z","timestamp":1555096152000},"source":"Crossref","is-referenced-by-count":99,"title":["AIRE expression controls the peripheral selection of autoreactive B cells"],"prefix":"10.1126","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5623-8873","authenticated-orcid":true,"given":"Joel","family":"Sng","sequence":"first","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-2960","authenticated-orcid":true,"given":"Burcu","family":"Ayoglu","sequence":"additional","affiliation":[{"name":"School of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3371-7820","authenticated-orcid":true,"given":"Jeff W.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Nicolas","family":"Schickel","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3285-7768","authenticated-orcid":true,"given":"Elise M. N.","family":"Ferre","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salom\u00e9","family":"Glauzy","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1881-5318","authenticated-orcid":true,"given":"Neil","family":"Romberg","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA."},{"name":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9165-1690","authenticated-orcid":true,"given":"Manfred","family":"Hoenig","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Medical Centre Ulm, Ulm, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0725-0320","authenticated-orcid":true,"given":"Charlotte","family":"Cunningham-Rundles","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Medicine, Icahn School of Medicine, Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1181-1565","authenticated-orcid":true,"given":"Paul J.","family":"Utz","sequence":"additional","affiliation":[{"name":"School of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA."},{"name":"Institute for Immunity, Transplantation, and Infection (ITI), Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4994-9500","authenticated-orcid":true,"given":"Michail S.","family":"Lionakis","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4326-0171","authenticated-orcid":true,"given":"Eric","family":"Meffre","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1297-393"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ng1297-399","article-title":"An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains","volume":"17","author":"Finnish-German APECED Consortium","year":"1997","unstructured":"Finnish-German APECED Consortium, An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat. Genet. 17, 399\u2013403 (1997).","journal-title":"Nat. Genet."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1075958"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12024"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.4.397"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050471"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.07.005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20102327"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061864"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.009"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa7017"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806874105"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.6.4072"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1172\/JCI32405","article-title":"Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice","volume":"117","author":"Hu C. Y.","year":"2007","unstructured":"C. Y. Hu, D. Rodriguez-Pinto, W. du, A. Ahuja, O. Henegariu, F. S. Wong, M. J. Shlomchik, L. Wen, Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. J. Clin. Invest. 117, 3857\u20133867 (2007).","journal-title":"J. Clin. Invest."},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1365-2249.2004.02384.x","article-title":"Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED): A model disease to study molecular aspects of endocrine autoimmunity","volume":"135","author":"Peterson P.","year":"2004","unstructured":"P. Peterson, J. Pitk\u00e4nen, N. Sillanp\u00e4\u00e4, K. Krohn, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED): A model disease to study molecular aspects of endocrine autoimmunity. Clin. Exp. Immunol. 135, 348\u2013357 (2004).","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00428779","article-title":"Autoantibodies against a novel 51 kDa islet antigen and glutamate decarboxylase isoforms in autoimmune polyendocrine syndrome type I","volume":"37","author":"Velloso L. A.","year":"1994","unstructured":"L. A. Velloso, O. Winqvist, J. Gustafsson, O. K\u00e4mpe, F. A. Karlsson, Autoantibodies against a novel 51 kDa islet antigen and glutamate decarboxylase isoforms in autoimmune polyendocrine syndrome type I. Diabetologia 37, 61\u201369 (1994).","journal-title":"Diabetologia"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091669"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091983"},{"key":"e_1_3_2_20_2","first-page":"e88782","article-title":"Redefined clinical features and diagnostic criteria in autoimmune polyendocrinopathy-candidiasis\u2013ectodermal dystrophy","volume":"1","author":"Ferre E. M. N.","year":"2016","unstructured":"E. M. N. Ferre, S. R. Rose, S. D. Rosenzweig, P. D. Burbelo, K. R. Romito, J. E. Niemela, L. B. Rosen, T. J. Break, W. Gu, S. Hunsberger, S. K. Browne, A. P. Hsu, S. Rampertaap, M. Swamydas, A. L. Collar, H. H. Kong, C. C. R. Lee, D. Chascsa, T. Simcox, A. Pham, A. Bondici, M. Natarajan, J. Monsale, D. E. Kleiner, M. Quezado, I. Alevizos, N. M. Moutsopoulos, L. Yockey, C. Frein, A. Soldatos, K. R. Calvo, J. Adjemian, M. N. Similuk, D. M. Lang, K. D. Stone, G. Uzel, J. B. Kopp, R. J. Bishop, S. M. Holland, K. N. Olivier, T. A. Fleisher, T. Heller, K. K. Winer, M. S. Lionakis, Redefined clinical features and diagnostic criteria in autoimmune polyendocrinopathy-candidiasis\u2013ectodermal dystrophy. JCI Insight 1, e88782 (2016).","journal-title":"JCI Insight"},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s10875-013-9938-6","article-title":"Anti-cytokine autoantibodies preceding onset of autoimmune polyendocrine syndrome type I features in early childhood","volume":"33","author":"Wolff A. S. B.","year":"2013","unstructured":"A. S. B. Wolff, A. K. Sarkadi, L. Mar\u00f3di, J. K\u00e4rner, \u00c9. Orlova, B. E. V. Oftedal, K. Kisand, E. Ol\u00e1h, A. Meloni, A. G. Myhre, E. S. Husebye, R. Motaghedi, J. Perheentupa, P. Peterson, N. Willcox, A. Meager, Anti-cytokine autoantibodies preceding onset of autoimmune polyendocrine syndrome type I features in early childhood. J. Clin. Immunol. 33, 1341\u20131348 (2013).","journal-title":"J. Clin. Immunol."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086907"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1172\/JCI61788","article-title":"Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapy","volume":"122","author":"Sauer A. V.","year":"2012","unstructured":"A. V. Sauer, H. Morbach, I. Brigida, Y.-S. Ng, A. Aiuti, E. Meffre, Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapy. J. Clin. Invest. 122, 2141\u20132152 (2012).","journal-title":"J. Clin. Invest."},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1084\/jem.20062287","article-title":"CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance","volume":"204","author":"Herv\u00e9 M.","year":"2007","unstructured":"M. Herv\u00e9, I. Isnardi, Y. S. Ng, J. B. Bussel, H. D. Ochs, C. Cunningham-Rundles, E. Meffre, CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance. J. Exp. Med. 204, 1583\u20131593 (2007).","journal-title":"J. Exp. Med."},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.jaci.2014.07.042","article-title":"Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells","volume":"134","author":"Janssen E.","year":"2014","unstructured":"E. Janssen, H. Morbach, S. Ullas, J. M. Bannock, C. Massad, L. Menard, I. Barlan, G. Lefranc, H. Su, M. Dasouki, W. al-Herz, S. Keles, T. Chatila, R. S. Geha, E. Meffre, Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells. J. Allergy Clin. Immunol. 134, 1365\u20131374 (2014).","journal-title":"J. Allergy Clin. Immunol."},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1172\/JCI82249","article-title":"Lentiviral-mediated gene therapy restores B cell tolerance in Wiskott-Aldrich syndrome patients","volume":"125","author":"Pala F.","year":"2015","unstructured":"F. Pala, H. Morbach, M. C. Castiello, J.-N. Schickel, S. Scaramuzza, N. Chamberlain, B. Cassani, S. Glauzy, N. Romberg, F. Candotti, A. Aiuti, M. Bosticardo, A. Villa, E. Meffre, Lentiviral-mediated gene therapy restores B cell tolerance in Wiskott-Aldrich syndrome patients. J. Clin. Invest. 125, 3941\u20133951 (2015).","journal-title":"J. Clin. Invest."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-457465"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040920"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.immuni.2008.09.015","article-title":"IRAK-4\u2013 and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans","volume":"29","author":"Isnardi I.","year":"2008","unstructured":"I. Isnardi, Y. S. Ng, I. Srdanovic, R. Motaghedi, S. Rudchenko, H. von Bernuth, S. Y. Zhang, A. Puel, E. Jouanguy, C. Picard, B. Z. Garty, Y. Camcioglu, R. Doffinger, D. Kumararatne, G. Davies, J. I. Gallin, S. Haraguchi, N. K. Day, J. L. Casanova, E. Meffre, IRAK-4\u2013 and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans. Immunity 29, 746\u2013757 (2008).","journal-title":"Immunity"},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1182\/blood-2009-09-243071","article-title":"Complement receptor 2\/CD21\u2013 human naive B cells contain mostly autoreactive unresponsive clones","volume":"115","author":"Isnardi I.","year":"2010","unstructured":"I. Isnardi, Y.-S. Ng, L. Menard, G. Meyers, D. Saadoun, I. Srdanovic, J. Samuels, J. Berman, J. H. Buckner, C. Cunningham-Rundles, E. Meffre, Complement receptor 2\/CD21\u2013 human naive B cells contain mostly autoreactive unresponsive clones. Blood 115, 5026\u20135036 (2010).","journal-title":"Blood"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/art.37828","article-title":"Expansion of autoreactive unresponsive CD21\u2212\/low B cells in Sj\u00f6gren\u2019s syndrome-associated lymphoproliferation","volume":"65","author":"Saadoun D.","year":"2013","unstructured":"D. Saadoun, B. Terrier, J. Bannock, T. Vazquez, C. Massad, I. Kang, F. Joly, M. Rosenzwajg, D. Sene, P. Benech, L. Musset, D. Klatzmann, E. Meffre, P. Cacoub, Expansion of autoreactive unresponsive CD21\u2212\/low B cells in Sj\u00f6gren\u2019s syndrome-associated lymphoproliferation. Arthritis Rheum. 65, 1085\u20131096 (2013).","journal-title":"Arthritis Rheum."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801859"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20132203"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060964"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2572"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.11.004"},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1172\/JCI69854","article-title":"CVID-associated TACI mutations affect autoreactive B cell selection and activation","volume":"123","author":"Romberg N.","year":"2013","unstructured":"N. Romberg, N. Chamberlain, D. Saadoun, M. Gentile, T. Kinnunen, Y. S. Ng, M. Virdee, L. Menard, T. Cantaert, H. Morbach, R. Rachid, N. Martinez-Pomar, N. Matamoros, R. Geha, B. Grimbacher, A. Cerutti, C. Cunningham-Rundles, E. Meffre, CVID-associated TACI mutations affect autoreactive B cell selection and activation. J. Clin. Invest. 123, 4283\u20134293 (2013).","journal-title":"J. Clin. Invest."},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.jaci.2013.10.051","article-title":"Signaling lymphocytic activation molecule (SLAM)\/SLAM-associated protein pathway regulates human B-cell tolerance","volume":"133","author":"Menard L.","year":"2014","unstructured":"L. Menard, T. Cantaert, N. Chamberlain, S. G. Tangye, S. Riminton, J. A. Church, A. Klion, C. Cunningham-Rundles, K. E. Nichols, E. Meffre, Signaling lymphocytic activation molecule (SLAM)\/SLAM-associated protein pathway regulates human B-cell tolerance. J. Allergy Clin. Immunol. 133, 1149\u20131161 (2014).","journal-title":"J. Allergy Clin. Immunol."},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84645"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.171645.113"},{"key":"e_1_3_2_41_2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0065-2776(08)60633-1","article-title":"Self-tolerance checkpoints in B lymphocyte development","volume":"59","author":"Goodnow C. C.","year":"1995","unstructured":"C. C. Goodnow, J. G. Cyster, S. B. Hartley, S. E. Bell, M. P. Cooke, J. I. Healy, S. Akkaraju, J. C. Rathmell, S. L. Pogue, K. P. Shokat, Self-tolerance checkpoints in B lymphocyte development. Adv. Immunol. 59, 279\u2013368 (1995).","journal-title":"Adv. Immunol."},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.19"},{"key":"e_1_3_2_43_2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.imbio.2012.02.005","article-title":"Expression profile of peripheral tissue antigen genes in medullary thymic epithelial cells (mTECs) is dependent on mRNA levels of autoimmune regulator (Aire)","volume":"218","author":"Oliveira E. H.","year":"2013","unstructured":"E. H. Oliveira, C. Macedo, P. B. Donate, R. S. Almeida, N. Pezzi, C. Nguyen, M. A. Rossi, E. T. Sakamoto-Hojo, E. A. Donadi, G. A. Passos, Expression profile of peripheral tissue antigen genes in medullary thymic epithelial cells (mTECs) is dependent on mRNA levels of autoimmune regulator (Aire). Immunobiology 218, 96\u2013104 (2013).","journal-title":"Immunobiology"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.8.4622"},{"key":"e_1_3_2_45_2","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1101\/gad.8.9.1030","article-title":"Functional immunoglobulin transgenes guide ordered B cell differentiation in Rag-1\u2013deficient mice","volume":"8","author":"Spanopoulou E.","year":"1994","unstructured":"E. Spanopoulou, C. A. J. Roman, L. M. Corcoran, M. S. Schlissel, D. P. Silver, D. Nemazee, M. C. Nussenzweig, S. A. Shinton, R. R. Hardy, D. Baltimore, Functional immunoglobulin transgenes guide ordered B cell differentiation in Rag-1\u2013deficient mice. Genes Dev. 8, 1030\u20131042 (1994).","journal-title":"Genes Dev."},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102600108"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.10.002"},{"key":"e_1_3_2_48_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cyto.2012.06.285","article-title":"TWEAK promotes the production of interleukin-17 in rheumatoid arthritis","volume":"60","author":"Park J. S.","year":"2012","unstructured":"J. S. Park, M.-K. Park, S.-Y. Lee, H.-J. Oh, M.-A. Lim, W.-T. Cho, E.-K. Kim, J.-H. Ju, Y.-W. Park, S.-H. Park, M.-L. Cho, H.-Y. Kim, TWEAK promotes the production of interleukin-17 in rheumatoid arthritis. Cytokine 60, 143\u2013149 (2012).","journal-title":"Cytokine"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.06.024"},{"key":"e_1_3_2_50_2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.immuni.2016.10.023","article-title":"Aire inhibits the generation of a perinatal population of interleukin-17A-producing \u03b3\u03b4 T cells to promote immunologic tolerance","volume":"45","author":"Fujikado N.","year":"2016","unstructured":"N. Fujikado, A. O. Mann, K. Bansal, K. R. Romito, E. M. N. Ferre, S. D. Rosenzweig, M. S. Lionakis, C. Benoist, D. Mathis, Aire inhibits the generation of a perinatal population of interleukin-17A-producing \u03b3\u03b4 T cells to promote immunologic tolerance. Immunity 45, 999\u20131012 (2016).","journal-title":"Immunity"},{"key":"e_1_3_2_51_2","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1172\/JCI91162","article-title":"Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency","volume":"126","author":"Walter J. E.","year":"2016","unstructured":"J. E. Walter, L. B. Rosen, K. Csomos, J. M. Rosenberg, D. Mathew, M. Keszei, B. Ujhazi, K. Chen, Y. N. Lee, I. Tirosh, K. Dobbs, W. al-Herz, M. J. Cowan, J. Puck, J. J. Bleesing, M. S. Grimley, H. Malech, S. S. de Ravin, A. R. Gennery, R. S. Abraham, A. Y. Joshi, T. G. Boyce, M. J. Butte, K. C. Nadeau, I. Balboni, K. E. Sullivan, J. Akhter, M. Adeli, R. A. el-Feky, D. H. el-Ghoneimy, G. Dbaibo, R. Wakim, C. Azzari, P. Palma, C. Cancrini, K. Capuder, A. Condino-Neto, B. T. Costa-Carvalho, J. B. Oliveira, C. Roifman, D. Buchbinder, A. Kumanovics, J. L. Franco, T. Niehues, C. Schuetz, T. Kuijpers, C. Yee, J. Chou, M. J. Masaad, R. Geha, G. Uzel, R. Gelman, S. M. Holland, M. Recher, P. J. Utz, S. K. Browne, L. D. Notarangelo, Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency. J. Clin. Invest. 126, 4389 (2016).","journal-title":"J. Clin. Invest."},{"key":"e_1_3_2_52_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1182\/blood-2009-03-211029","article-title":"Early defects in human T-cell development severely affect distribution and maturation of thymic stromal cells: Possible implications for the pathophysiology of Omenn syndrome","volume":"114","author":"Poliani P. L.","year":"2009","unstructured":"P. L. Poliani, F. Facchetti, M. Ravanini, A. R. Gennery, A. Villa, C. M. Roifman, L. D. Notarangelo, Early defects in human T-cell development severely affect distribution and maturation of thymic stromal cells: Possible implications for the pathophysiology of Omenn syndrome. Blood 114, 105\u2013108 (2009).","journal-title":"Blood"},{"key":"e_1_3_2_53_2","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.4049\/jimmunol.178.2.1208","article-title":"A defect of regulatory T cells in patients with autoimmune polyendocrinopathy-candidiasis\u2013ectodermal dystrophy","volume":"178","author":"Kek\u00e4l\u00e4inen E.","year":"2007","unstructured":"E. Kek\u00e4l\u00e4inen, H. Tuovinen, J. Joensuu, M. Gylling, R. Franssila, N. Pontynen, K. Talvensaari, J. Perheentupa, A. Miettinen, T. P. Arstila, A defect of regulatory T cells in patients with autoimmune polyendocrinopathy-candidiasis\u2013ectodermal dystrophy. J. Immunol. 178, 1208\u20131215 (2007).","journal-title":"J. Immunol."},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni906"},{"key":"e_1_3_2_55_2","doi-asserted-by":"crossref","first-page":"14890","DOI":"10.1073\/pnas.1103810108","article-title":"CD4+CD25+Foxp3+ regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletion","volume":"108","author":"Cozzo Picca C.","year":"2011","unstructured":"C. Cozzo Picca, D. M. Simons, S. Oh, M. Aitken, O. A. Perng, C. Mergenthaler, E. Kropf, J. Erikson, A. J. Caton, CD4+CD25+Foxp3+ regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletion. Proc. Natl. Acad. Sci. U.S.A. 108, 14890\u201314895 (2011).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.05.013"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1159407"},{"key":"e_1_3_2_58_2","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.4049\/jimmunol.181.7.4447","article-title":"Cutting edge: CD25+ regulatory T cells prevent expansion and induce apoptosis of B cells specific for tissue autoantigens","volume":"181","author":"Ludwig-Portugall I.","year":"2008","unstructured":"I. Ludwig-Portugall, E. E. Hamilton-Williams, C. Gottschalk, C. Kurts, Cutting edge: CD25+ regulatory T cells prevent expansion and induce apoptosis of B cells specific for tissue autoantigens. J. Immunol. 181, 4447\u20134451 (2008).","journal-title":"J. Immunol."},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-11-4502"},{"key":"e_1_3_2_60_2","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.4049\/jimmunol.0901163","article-title":"Cutting edge: Regulatory T cells directly suppress B cells in systemic lupus erythematosus","volume":"183","author":"Iikuni N.","year":"2009","unstructured":"N. Iikuni, E. V. Lourenco, B. H. Hahn, A. la Cava, Cutting edge: Regulatory T cells directly suppress B cells in systemic lupus erythematosus. J. Immunol. 183, 1518\u20131522 (2009).","journal-title":"J. Immunol."},{"key":"e_1_3_2_61_2","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.4049\/jimmunol.1402960","article-title":"Distinct modes of antigen presentation promote the formation, differentiation, and activity of foxp3+ regulatory T cells in vivo","volume":"194","author":"Weissler K. A.","year":"2015","unstructured":"K. A. Weissler, V. Garcia, E. Kropf, M. Aitken, F. Bedoya, A. I. Wolf, J. Erikson, A. J. Caton, Distinct modes of antigen presentation promote the formation, differentiation, and activity of foxp3+ regulatory T cells in vivo. J. Immunol. 194, 3784\u20133797 (2015).","journal-title":"J. Immunol."},{"key":"e_1_3_2_62_2","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.jaci.2011.05.031","article-title":"Hematopoietic stem cell transplantation for CD3\u03b4 deficiency","volume":"128","author":"Marcus N.","year":"2011","unstructured":"N. Marcus, H. Takada, J. Law, M. J. Cowan, J. Gil, J. R. Regueiro, D. Plaza Lopez de Sabando, E. Lopez-Granados, J. Dalal, W. Friedrich, H. Manfred, I. C. Hanson, E. Grunebaum, W. T. Shearer, C. M. Roifman, Hematopoietic stem cell transplantation for CD3\u03b4 deficiency. J. Allergy Clin. Immunol. 128, 1050\u20131057 (2011).","journal-title":"J. Allergy Clin. Immunol."},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1518553113"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.07.026"},{"key":"e_1_3_2_65_2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ab.2005.09.034","article-title":"Analyzing a kinetic titration series using affinity biosensors","volume":"349","author":"Karlsson R.","year":"2006","unstructured":"R. Karlsson, P. S. Katsamba, H. Nordin, E. Pol, D. G. Myszka, Analyzing a kinetic titration series using affinity biosensors. Anal. Biochem. 349, 136\u2013147 (2006).","journal-title":"Anal. Biochem."}],"container-title":["Science Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/sciimmunol.aav6778","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciimmunol.aav6778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T07:48:15Z","timestamp":1705391295000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.aav6778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,12]]},"references-count":64,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2019,4,12]]}},"alternative-id":["10.1126\/sciimmunol.aav6778"],"URL":"https:\/\/doi.org\/10.1126\/sciimmunol.aav6778","relation":{},"ISSN":["2470-9468"],"issn-type":[{"value":"2470-9468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,12]]},"article-number":"eaav6778"}}