{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:04:49Z","timestamp":1753880689857,"version":"3.41.2"},"reference-count":10,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"32","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2019,2,8]]},"abstract":"<jats:p>\n            HLA haplotypes in conjunction with serum anticommensal antibody responses are predictive of type 1 diabetes progression. See related Research Article by\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/immunology.sciencemag.org\/content\/4\/32\/eaau8125.full\">\n              Paun\n              <jats:italic>et al<\/jats:italic>\n              .\n            <\/jats:ext-link>\n          <\/jats:p>","DOI":"10.1126\/sciimmunol.aaw3345","type":"journal-article","created":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T00:07:20Z","timestamp":1549066040000},"source":"Crossref","is-referenced-by-count":0,"title":["A perfect storm: Genetics and anticommensal antibodies shore up type 1 diabetes"],"prefix":"10.1126","volume":"4","author":[{"given":"Jacob M.","family":"Luber","sequence":"first","affiliation":[{"name":"Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA 02215, USA."},{"name":"Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA 02215, USA."},{"name":"Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA."},{"name":"Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0837-4360","authenticated-orcid":true,"given":"Aleksandar D.","family":"Kostic","sequence":"additional","affiliation":[{"name":"Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA 02215, USA."},{"name":"Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA 02215, USA."},{"name":"Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aau8125"},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1136\/thorax.55.suppl_1.S2","article-title":"Family size, infection and atopy: The first decade of the \u201chygiene hypothesis.\u201d","volume":"55","author":"Strachan D. P.","year":"2000","unstructured":"D. P. Strachan, Family size, infection and atopy: The first decade of the \u201chygiene hypothesis.\u201d Thorax 55, S2\u2013S10 (2000).","journal-title":"Thorax"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.111"},{"key":"e_1_3_1_5_2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.chom.2016.06.009","article-title":"The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes","volume":"20","author":"Kostic A. D.","year":"2016","unstructured":"A. D. Kostic, D. Gevers, H. Siljander, T. Vatanen, T. Hy\u00f6tyl\u00e4inen, A. M. H\u00e4m\u00e4l\u00e4inen, A. Peet, V. Tillmann, P. P\u00f6h\u00f6, I. Mattila, H. L\u00e4hdesm\u00e4ki, E. A. Franzosa, O. Vaarala, M. de Goffau, H. Harmsen, J. Ilonen, S. M. Virtanen, C. B. Clish, M. Ore\u0161i\u010d, C. Huttenhower, M. Knip, R. J. Xavier, The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host Microbe 20, 121 (2016).","journal-title":"Cell Host Microbe"},{"key":"e_1_3_1_6_2","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.cell.2016.05.056","article-title":"Variation in microbiome lps immunogenicity contributes to autoimmunity in humans","volume":"165","author":"Vatanen T.","year":"2016","unstructured":"T. Vatanen, A. D. Kostic, E. d'Hennezel, H. Siljander, E. A. Franzosa, M. Yassour, R. Kolde, H. Vlamakis, T. D. Arthur, A. M. H\u00e4m\u00e4l\u00e4inen, A. Peet, V. Tillmann, R. Uibo, S. Mokurov, N. Dorshakova, J. Ilonen, S. M. Virtanen, S. J. Szabo, J. A. Porter, H. L\u00e4hdesm\u00e4ki, C. Huttenhower, D. Gevers, T. W. Cullen, M. Knip; DIABIMMUNE Study Group, R. J. Xavier, Variation in microbiome lps immunogenicity contributes to autoimmunity in humans. Cell 165, 1551 (2016).","journal-title":"Cell"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0620-2"},{"key":"e_1_3_1_8_2","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1399-5448.2007.00269.x","article-title":"The Environmental Determinants of Diabetes in the Young (TEDDY) study: Study design","volume":"8","author":"The TEDDY Study Group","year":"2007","unstructured":"The TEDDY Study Group, The Environmental Determinants of Diabetes in the Young (TEDDY) study: Study design. Pediatr. Diabetes 8, 286\u2013298 (2007).","journal-title":"Pediatr. Diabetes"},{"key":"e_1_3_1_9_2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1196\/annals.1447.054","article-title":"Type 1 Diabetes TrialNet\u2014An international collaborative clinical trials network","volume":"1150","author":"Skyler J. S.","year":"2008","unstructured":"J. S. Skyler, C. J. Greenbaum, J. M. Lachin, E. Leschek, L. Rafkin-Mervis, P. Savage, L. Spain; the Type 1 Diabetes TrialNet Study Group, Type 1 Diabetes TrialNet\u2014An international collaborative clinical trials network. Ann. N. Y. Acad. Sci. 1150, 14\u201324 (2008).","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.143"},{"key":"e_1_3_1_11_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/CS20120627","article-title":"Advances in our understanding of the pathophysiology of Type 1 diabetes: Lessons from the NOD mouse","volume":"126","author":"Jayasimhan A.","year":"2014","unstructured":"A. Jayasimhan, K. P. Mansour, R. M. Slattery, Advances in our understanding of the pathophysiology of Type 1 diabetes: Lessons from the NOD mouse. Clin. Sci. 126, 1\u201318 (2014).","journal-title":"Clin. Sci."}],"container-title":["Science Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciimmunol.aaw3345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:05:18Z","timestamp":1705410318000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.aaw3345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,8]]},"references-count":10,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2019,2,8]]}},"alternative-id":["10.1126\/sciimmunol.aaw3345"],"URL":"https:\/\/doi.org\/10.1126\/sciimmunol.aaw3345","relation":{},"ISSN":["2470-9468"],"issn-type":[{"type":"electronic","value":"2470-9468"}],"subject":[],"published":{"date-parts":[[2019,2,8]]},"article-number":"eaaw3345"}}