{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:56:27Z","timestamp":1790222187476,"version":"4.1.0"},"reference-count":69,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"59","funder":[{"DOI":"10.13039\/100010438","name":"Francis Crick Institute","doi-asserted-by":"publisher","award":["FC001206"],"award-info":[{"award-number":["FC001206"]}],"id":[{"id":"10.13039\/100010438","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["STA 338\/15-1"],"award-info":[{"award-number":["STA 338\/15-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BO 4340\/1-1"],"award-info":[{"award-number":["BO 4340\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1129"],"award-info":[{"award-number":["SFB1129"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR186"],"award-info":[{"award-number":["TRR186"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["STA 1536\/2-1"],"award-info":[{"award-number":["STA 1536\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1160"],"award-info":[{"award-number":["SFB 1160"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Excellence Initiative of the German Research Foundation","award":["GSC-4"],"award-info":[{"award-number":["GSC-4"]}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["DOC 32-B28 and SFB-F6101"],"award-info":[{"award-number":["DOC 32-B28 and SFB-F6101"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2021,5,28]]},"abstract":"<jats:p>TYK2 is required for efficient IFN-\u03b1\/\u03b2 signaling but dispensable for IFN-\u03bb\u2013mediated antiviral protection in epithelial cells.<\/jats:p>","DOI":"10.1126\/sciimmunol.abd5318","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T19:10:17Z","timestamp":1621019417000},"source":"Crossref","is-referenced-by-count":42,"title":["Selective Janus kinase inhibition preserves interferon-\u03bb\u2013mediated antiviral responses"],"prefix":"10.1126","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7528-981X","authenticated-orcid":true,"given":"Daniel","family":"Schnepf","sequence":"first","affiliation":[{"name":"Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany."},{"name":"Spemann Graduate School of Biology and Medicine, Albert Ludwigs University Freiburg, Freiburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4676-8616","authenticated-orcid":true,"given":"Stefania","family":"Crotta","sequence":"additional","affiliation":[{"name":"Immunoregulation Laboratory, The Francis Crick Institute, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9824-6639","authenticated-orcid":true,"given":"Thiprampai","family":"Thamamongood","sequence":"additional","affiliation":[{"name":"Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany."},{"name":"Spemann Graduate School of Biology and Medicine, Albert Ludwigs University Freiburg, Freiburg, Germany."},{"name":"Faculty of Biology, University of Freiburg, Freiburg, Germany."},{"name":"Faculty of Medicine, University of Freiburg, Freiburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5606-1297","authenticated-orcid":true,"given":"Megan","family":"Stanifer","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Polcik","sequence":"additional","affiliation":[{"name":"Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4356-3175","authenticated-orcid":true,"given":"Annette","family":"Ohnemus","sequence":"additional","affiliation":[{"name":"Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Vier","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Medical Microbiology and Hygiene, Medical Center University of Freiburg, Freiburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2831-0268","authenticated-orcid":true,"given":"Celia","family":"Jakob","sequence":"additional","affiliation":[{"name":"Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2582-6602","authenticated-orcid":true,"given":"Miriam","family":"Llorian","sequence":"additional","affiliation":[{"name":"Bioinformatics and Biostatistics, The Francis Crick Institute, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8449-1115","authenticated-orcid":true,"given":"Hans Henrik","family":"Gad","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1159-066X","authenticated-orcid":true,"given":"Rune","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5716-3212","authenticated-orcid":true,"given":"Birgit","family":"Strobl","sequence":"additional","affiliation":[{"name":"Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7771-7817","authenticated-orcid":true,"given":"Susanne","family":"Kirschnek","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Medical Microbiology and Hygiene, Medical Center University of Freiburg, Freiburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8614-4993","authenticated-orcid":true,"given":"Steeve","family":"Boulant","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Virology, Heidelberg University, Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2972-6855","authenticated-orcid":true,"given":"Martin","family":"Schwemmle","sequence":"additional","affiliation":[{"name":"Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany."},{"name":"Faculty of Medicine, University of Freiburg, Freiburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5226-2991","authenticated-orcid":true,"given":"Andreas","family":"Wack","sequence":"additional","affiliation":[{"name":"Immunoregulation Laboratory, The Francis Crick Institute, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7057-6177","authenticated-orcid":true,"given":"Peter","family":"Staeheli","sequence":"additional","affiliation":[{"name":"Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany."},{"name":"Faculty of Medicine, University of Freiburg, Freiburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI98814"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806382"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.201"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.025"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.02.017"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2807"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.4049\/jimmunol.155.3.1079","article-title":"IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes","volume":"155","author":"Finbloom D. S.","year":"1995","unstructured":"D. S. Finbloom, K. D. Winestock, IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes. J. Immunol. 155, 1079\u20131090 (1995).","journal-title":"J. Immunol."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.9.5043"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.42.26388"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2016.03.023"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0182-z"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646519"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20140280"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00054-6"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13992"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.22982"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni875"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni873"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200653"},{"key":"e_1_3_2_21_2","first-page":"1410","article-title":"Weak induction of interferon expression by SARS-Cov-2 supports clinical trials of interferon lambda to treat early COVID-19","volume":"71","author":"O\u2019Brien T. R.","year":"2020","unstructured":"T. R. O\u2019Brien, D. L. Thomas, S. S. Jackson, L. Prokunina-Olsson, R. P. Donnelly, R. Hartmann, Weak induction of interferon expression by SARS-Cov-2 supports clinical trials of interferon lambda to treat early COVID-19. Clin. Infect. Dis. 71, 1410\u20131412 (2020).","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202012465"},{"key":"e_1_3_2_23_2","article-title":"Peginterferon-lambda for the treatment of COVID-19 in outpatients","author":"Feld J. J.","year":"2020","unstructured":"J. J. Feld, C. Kandel, M. J. Biondi, R. A. Kozak, M. A. Zahoor, C. Lemieux, S. M. Borgia, A. K. Boggild, J. Powis, J. McCready, D. H. S. Tan, T. Chan, B. Coburn, D. Kumar, A. Humar, A. Chan, B. O\u2019Neil, S. Noureldin, J. Booth, R. Hong, D. Smookler, W. Aleyadeh, A. Patel, B. Barber, J. Casey, R. Hiebert, H. Mistry, I. Choong, C. Hislop, D. M. Santer, D. L. Tyrrell, J. S. Glenn, A. J. Gehring, H. L. A. Janssen, B. Hansen, Peginterferon-lambda for the treatment of COVID-19 in outpatients. medRxiv 2020.2011.2009.20228098 (2020).","journal-title":"medRxiv"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00749"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33354"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.04.025"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2018.08.008"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07993-2"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7232361"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003773"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606413"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4864"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc2061"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc3545"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1916897117"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aap9614"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2019.0036"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20140995"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aan5357"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3821"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90105-L"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.2741\/3908"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.06.085"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2915"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2012.1064"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw1736"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910170110"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07935"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004782"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth865"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2510"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.01.011"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10348"},{"key":"e_1_3_2_54_2","first-page":"2100","article-title":"KBM-7, a human myeloid leukemia cell line with double Philadelphia chromosomes lacking normal c-ABL and BCR transcripts","volume":"9","author":"Andersson B. S.","year":"1995","unstructured":"B. S. Andersson, V. P. Collins, R. Kurzrock, D. W. Larkin, C. Childs, A. Ost, A. Cork, J. M. Trujillo, E. J. Freireich, M. J. Siciliano, KBM-7, a human myeloid leukemia cell line with double Philadelphia chromosomes lacking normal c-ABL and BCR transcripts. Leukemia 9, 2100\u20132108 (1995).","journal-title":"Leukemia"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1905633"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aav7501"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-018-0748-y"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061445"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000151"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-68-3-945"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701849104"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0955-3"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247005"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.143"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-323"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2008.87"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.8.6937-6945.1999"}],"container-title":["Science Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/sciimmunol.abd5318","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciimmunol.abd5318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:57:02Z","timestamp":1705409822000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.abd5318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,28]]},"references-count":69,"journal-issue":{"issue":"59","published-print":{"date-parts":[[2021,5,28]]}},"alternative-id":["10.1126\/sciimmunol.abd5318"],"URL":"https:\/\/doi.org\/10.1126\/sciimmunol.abd5318","relation":{},"ISSN":["2470-9468"],"issn-type":[{"value":"2470-9468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,28]]},"article-number":"eabd5318"}}