{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:47:03Z","timestamp":1791895623113,"version":"4.3.4"},"reference-count":55,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"59","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37AI052453"],"award-info":[{"award-number":["R37AI052453"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR076082"],"award-info":[{"award-number":["R01AR076082"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR074302"],"award-info":[{"award-number":["R01AR074302"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR069653"],"award-info":[{"award-number":["R01AR069653"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR074302"],"award-info":[{"award-number":["R01AR074302"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR076082"],"award-info":[{"award-number":["R01AR076082"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37AI052453"],"award-info":[{"award-number":["R37AI052453"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AI52038"],"award-info":[{"award-number":["U01AI52038"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011444","name":"Geochemical Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011444","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004848","name":"Universidad Veracruzana","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004848","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2021,5,28]]},"abstract":"<jats:p>Inhibition of HDAC8 and HDAC9 impairs keratinocyte tolerance of TLR ligand stimulation, leading to cutaneous inflammation.<\/jats:p>","DOI":"10.1126\/sciimmunol.abe1935","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T19:10:12Z","timestamp":1621624212000},"source":"Crossref","is-referenced-by-count":59,"title":["Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8\/9"],"prefix":"10.1126","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8793-708X","authenticated-orcid":true,"given":"Yu","family":"Sawada","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of California, San Diego, San Diego, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruaki","family":"Nakatsuji","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, San Diego, San Diego, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3678-6781","authenticated-orcid":true,"given":"Tatsuya","family":"Dokoshi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, San Diego, San Diego, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5321-1694","authenticated-orcid":true,"given":"Nikhil Nitin","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, San Diego, San Diego, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1402-9245","authenticated-orcid":true,"given":"Marc C.","family":"Liggins","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, San Diego, San Diego, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, San Diego, San Diego, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1401-7861","authenticated-orcid":true,"given":"Richard L.","family":"Gallo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, San Diego, San Diego, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0256-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2010.08.047"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5392.1338"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.54"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25177"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2016.07.007"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3661"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.06.021"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.04.022"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12726"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055380"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12721"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aah4609"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2864"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77088"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.05155-11"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2008"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800893"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-57294-x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010741107"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80215-9"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/22350"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.118.300943"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7839144"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.3.1247"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202012"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63610-3"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.10.037"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.311"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700902"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307761101"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700213"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020146"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.5.1563"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2861"},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4049\/jimmunol.161.1.241","article-title":"Fas\/Fas ligand interactions are involved in ultraviolet-B-induced human lymphocyte apoptosis","volume":"161","author":"Caricchio R.","year":"1998","unstructured":"R. Caricchio, E. A. Reap, P. L. Cohen, Fas\/Fas ligand interactions are involved in ultraviolet-B-induced human lymphocyte apoptosis. J. Immunol. 161, 241\u2013251 (1998).","journal-title":"J. Immunol."},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.4.711"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01608.x"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.06.019"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)70076-8"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1747.2004.22229.x"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06248-4"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2000.009003165.x"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.11.014"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.118624"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1383206"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20090870"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80903-4"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318668"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-019-01126-7"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067078"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/php.12628"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.12.035"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.07.814"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2006.00504.x"}],"container-title":["Science Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/sciimmunol.abe1935","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciimmunol.abe1935","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:57:40Z","timestamp":1705409860000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.abe1935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,28]]},"references-count":55,"journal-issue":{"issue":"59","published-print":{"date-parts":[[2021,5,28]]}},"alternative-id":["10.1126\/sciimmunol.abe1935"],"URL":"https:\/\/doi.org\/10.1126\/sciimmunol.abe1935","relation":{},"ISSN":["2470-9468"],"issn-type":[{"value":"2470-9468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,28]]},"article-number":"eabe1935"}}