{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:16:27Z","timestamp":1790435787494,"version":"4.1.0"},"reference-count":73,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"62","funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Konsul Bergh"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2021,8,10]]},"abstract":"<jats:p>Transcriptional profiling pinpoints the heterogeneity of T helper cells in human nasal polyps at the clonal level.<\/jats:p>","DOI":"10.1126\/sciimmunol.abg6356","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T19:21:11Z","timestamp":1628882471000},"source":"Crossref","is-referenced-by-count":79,"title":["Single-cell analysis pinpoints distinct populations of cytotoxic CD4\n            <sup>+<\/sup>\n            T cells and an IL-10\n            <sup>+<\/sup>\n            CD109\n            <sup>+<\/sup>\n            T\n            <sub>H<\/sub>\n            2 cell population in nasal polyps"],"prefix":"10.1126","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8449-6917","authenticated-orcid":true,"given":"Junjie","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7730-7700","authenticated-orcid":true,"given":"Christopher A.","family":"Tibbitt","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna Kumlien","family":"Geor\u00e9n","sequence":"additional","affiliation":[{"name":"Division of ENT Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden."},{"name":"Department of Otorhinolaryngology, Karolinska University Hospital, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8998-1367","authenticated-orcid":true,"given":"Murray","family":"Christian","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Murrell","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0538-9580","authenticated-orcid":true,"given":"Lars-Olaf","family":"Cardell","sequence":"additional","affiliation":[{"name":"Division of ENT Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden."},{"name":"Department of Otorhinolaryngology, Karolinska University Hospital, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4742-1665","authenticated-orcid":true,"given":"Claus","family":"Bachert","sequence":"additional","affiliation":[{"name":"Division of ENT Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden."},{"name":"Upper Airways Research Laboratory and Department of Oto-Rhino-Laryngology, Ghent University, Ghent, Belgium."},{"name":"First Affiliated Hospital, Sun Yat-sen University, International Airway Research Center, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5967-4857","authenticated-orcid":true,"given":"Jonathan M.","family":"Coquet","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3049"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00854.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.010"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00218-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri798"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2015.45"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.02.018"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80439-2"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80240-8"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.12.6930"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.4049\/jimmunol.162.3.1278","article-title":"Selective expression of a novel surface molecule by human Th2 cells in vivo","volume":"162","author":"Nagata K.","year":"1999","unstructured":"K. Nagata, K. Tanaka, K. Ogawa, K. Kemmotsu, T. Imai, O. Yoshie, H. Abe, K. Tada, M. Nakamura, K. Sugamura, S. Takano, Selective expression of a novel surface molecule by human Th2 cells in vivo. J. Immunol. 162, 1278\u20131286 (1999).","journal-title":"J. Immunol."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061675"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070406"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.08.015"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31881-1"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304048"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314768"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0449-8"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.031"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.05.014"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.10.131"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2012.02559.x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxl076"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aan8664"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.10.018"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0314-6"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aal5196"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20162069"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.207449"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.21"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.01.038"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0201-4"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.13129"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190490"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0893-x"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097581"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00194"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aat5943"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aba6087"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810769106"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.003"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0468-5"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.11.044"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI125917"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.279"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-020-00351-w"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-020-00339-6"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.04.021"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.06.010"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-1075fje"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90193-0"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90194-9"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08530"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3444"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0125-8"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxy201"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.12.001"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.05.045"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07581-4"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aal2192"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1539"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12798"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1907883116"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215753"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.3.1229"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0092-2019"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.587581"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.04.023"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.08.012"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57456"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11132"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13577"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0785-3"}],"container-title":["Science Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/sciimmunol.abg6356","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciimmunol.abg6356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:12:18Z","timestamp":1705410738000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.abg6356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,10]]},"references-count":73,"journal-issue":{"issue":"62","published-print":{"date-parts":[[2021,8,10]]}},"alternative-id":["10.1126\/sciimmunol.abg6356"],"URL":"https:\/\/doi.org\/10.1126\/sciimmunol.abg6356","relation":{},"ISSN":["2470-9468"],"issn-type":[{"value":"2470-9468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,10]]},"article-number":"eabg6356"}}