{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:48:44Z","timestamp":1792806524344,"version":"4.5.0"},"reference-count":109,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"64","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2021,10,29]]},"abstract":"<jats:p>\n                    Tumor-specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in stable tumor-draining lymph node reservoir are clonally and developmentally related to those in tumors.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.abg7836","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T14:01:51Z","timestamp":1630591311000},"source":"Crossref","is-referenced-by-count":431,"title":["A reservoir of stem-like CD8\n                    <sup>+<\/sup>\n                    T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response"],"prefix":"10.1126","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3403-1150","authenticated-orcid":true,"given":"Kelli A.","family":"Connolly","sequence":"first","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7512-9739","authenticated-orcid":true,"given":"Manik","family":"Kuchroo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0298-0172","authenticated-orcid":true,"given":"Aarthi","family":"Venkat","sequence":"additional","affiliation":[{"name":"Computational Biology and Bioinformatics Program, Yale University, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achia","family":"Khatun","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2627-4897","authenticated-orcid":true,"given":"Jiawei","family":"Wang","sequence":"additional","affiliation":[{"name":"Computational Biology and Bioinformatics Program, Yale University, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"William","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3503-7693","authenticated-orcid":true,"given":"Noah I.","family":"Hornick","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany L.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7217-3221","authenticated-orcid":true,"given":"Martina","family":"Damo","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5753-5335","authenticated-orcid":true,"given":"Moujtaba Y.","family":"Kasmani","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4736-4330","authenticated-orcid":true,"given":"Can","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0313-3717","authenticated-orcid":true,"given":"Eric","family":"Fagerberg","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3959-9324","authenticated-orcid":true,"given":"Isabel","family":"Monroy","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Hutchins","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1346-0930","authenticated-orcid":true,"given":"Julie F.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gena G.","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9369-2514","authenticated-orcid":true,"given":"Dylan L.","family":"Mariuzza","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mursal","family":"Nader","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1195-9607","authenticated-orcid":true,"given":"Hongyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Yale School of Public Health, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, USA."},{"name":"Versiti Blood Research Institute, Milwaukee, WI 53213, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5823-1985","authenticated-orcid":true,"given":"Smita","family":"Krishnaswamy","sequence":"additional","affiliation":[{"name":"Department of Genetics and Computer Science, Yale University School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-7837","authenticated-orcid":true,"given":"Nikhil S.","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.01.013"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1916623"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14011"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003689"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature21349"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.09.035"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/2051-1426-2-3"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.09.006"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00889-12"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.08.021"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aai8593"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100643"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.7.4204"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.8.4911-4927.2003"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610335104"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.7.3578-3600.2004"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.06.019"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000841"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58600-8"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.09.013"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080526"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.05.014"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.11.002"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1679"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02981"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1325-x"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1324-y"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1905675116"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1326-9"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature19330"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1902701116"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0312-6"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.12.021"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature19317"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3543"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180684"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1917298117"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1903520116"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.07.021"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.11.014"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1229620"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.04.014"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20150598"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2193"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1490"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09881"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.02.018"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.11.011"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.95"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10803"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.02.008"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1609376113"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.07.011"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.10.5282"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2634"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04524-x"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12591"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0613-1"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.08.006"},{"key":"e_1_3_3_61_2","first-page":"51","article-title":"A novel mouse model for the study of anti-tumor T cell responses in Kras driven lung adenocarcinoma","author":"Fitzgerald B.","year":"2021","unstructured":"B. Fitzgerald, K. Connolly, G. G. Foster, C. Cui, J. F. Cheung, E. Fagerberg, N. I. Hornick, D. L. Mariuzza, I. William, J. F. Cheung, N. Joshi, A novel mouse model for the study of anti-tumor T cell responses in Kras driven lung adenocarcinoma. Cell Rep. Methods , 51 (2021).","journal-title":"Cell Rep. Methods"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21619-0"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0403-4"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.10.018"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3706"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.052"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22367"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.08.013"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2745"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04444"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0336-3"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00456-9"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040760"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0591-3"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0800997"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050100"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061937"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.11.021"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110308"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16164-1"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05072-0"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300538"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-018-1080-0"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-18-0713"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23007"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05032-8"},{"key":"e_1_3_3_87_2","first-page":"e1204507","article-title":"Intratumoral expression levels of PD-L1, GZMA, and HLA-A along with oligoclonal T cell expansion associate with response to nivolumab in metastatic melanoma","volume":"5","author":"Inoue H.","year":"2016","unstructured":"H. Inoue, J. H. Park, K. Kiyotani, M. Zewde, A. Miyashita, M. Jinnin, Y. Kiniwa, R. Okuyama, R. Tanaka, Y. Fujisawa, H. Kato, A. Morita, J. Asai, N. Katoh, K. Yokota, M. Akiyama, H. Ihn, S. Fukushima, Y. Nakamura, Intratumoral expression levels of PD-L1, GZMA, and HLA-A along with oligoclonal T cell expansion associate with response to nivolumab in metastatic melanoma. Onco. Targets. Ther. 5, e1204507 (2016).","journal-title":"Onco. Targets. Ther."},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.10.038"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13954"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1836-5"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701269"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.09.007"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.04.003"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14404"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.01.072"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702579104"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.03.012"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.06.003"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-020-0075-x"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.09.001"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay3575"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-1449"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00125"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716078"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2056-8"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0522-3"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.07.010"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp335"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.05.061"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0414-6"}],"container-title":["Science Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciimmunol.abg7836","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T07:44:57Z","timestamp":1705391097000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.abg7836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,29]]},"references-count":109,"journal-issue":{"issue":"64","published-print":{"date-parts":[[2021,10,29]]}},"alternative-id":["10.1126\/sciimmunol.abg7836"],"URL":"https:\/\/doi.org\/10.1126\/sciimmunol.abg7836","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.01.27.428467","asserted-by":"object"}]},"ISSN":["2470-9468"],"issn-type":[{"value":"2470-9468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,29]]},"article-number":"eabg7836"}}