{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:38:42Z","timestamp":1787503122798,"version":"build-2736575974"},"reference-count":78,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"66","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2021,12,24]]},"abstract":"<jats:p>\n                    Tuft cells produce LTC\n                    <jats:sub>4<\/jats:sub>\n                    and IL-25, which cooperate to promote allergen-driven airway inflammation.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.abj0474","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T15:27:37Z","timestamp":1640100457000},"source":"Crossref","is-referenced-by-count":116,"title":["Tuft cell\u2013produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation"],"prefix":"10.1126","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2899-1366","authenticated-orcid":true,"given":"Saltanat","family":"Ualiyeva","sequence":"first","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Jeff and Penny Vinik Center for Allergic Disease Research, Brigham and Women\u2019s Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9490-7679","authenticated-orcid":true,"given":"Evan","family":"Lemire","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0448-487X","authenticated-orcid":true,"given":"Evelyn C.","family":"Aviles","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6807-7835","authenticated-orcid":true,"given":"Caitlin","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Jeff and Penny Vinik Center for Allergic Disease Research, Brigham and Women\u2019s Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3819-4395","authenticated-orcid":true,"given":"Amelia A.","family":"Boyd","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Jeff and Penny Vinik Center for Allergic Disease Research, Brigham and Women\u2019s Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juying","family":"Lai","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Jeff and Penny Vinik Center for Allergic Disease Research, Brigham and Women\u2019s Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Jeff and Penny Vinik Center for Allergic Disease Research, Brigham and Women\u2019s Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Monell Chemical Senses Center, Philadelphia, PA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-8811","authenticated-orcid":true,"given":"Nora A.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Jeff and Penny Vinik Center for Allergic Disease Research, Brigham and Women\u2019s Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2401-2351","authenticated-orcid":true,"given":"Joshua A.","family":"Boyce","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Jeff and Penny Vinik Center for Allergic Disease Research, Brigham and Women\u2019s Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4229-2852","authenticated-orcid":true,"given":"Adam L.","family":"Haber","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1141-1529","authenticated-orcid":true,"given":"Lora G.","family":"Bankova","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Jeff and Penny Vinik Center for Allergic Disease Research, Brigham and Women\u2019s Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.06.036"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.07.007"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161274"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.03.048"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601569"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.06.007"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24029"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.10.001"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0393-7"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-11-3"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00032.2019"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019418108"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aat9453"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1531172100"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-9-115"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aax7224"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189340"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.06.016"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24489"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.046"},{"key":"e_1_3_3_22_2","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1111\/all.13700","article-title":"House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions","volume":"74","author":"Henkel F. D. R.","year":"2019","unstructured":"F. D. R. Henkel, A. Friedl, M. Haid, D. Thomas, T. Bouchery, P. Haimerl, M. de Los Reyes Jimenez, F. Alessandrini, C. B. Schmidt-Weber, N. L. Harris, J. Adamski, J. E.-v. Bieren, House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions. Allergy 74, 1090\u20131101 (2019).","journal-title":"Allergy"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.6.3710"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-3278(03)00074-7"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.24.8399"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-384826"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113396"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/21658"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep20461"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003490200"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C113.453704"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071371"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.2.1119"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.74"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100793"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3078"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500436"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900254"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature16161"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.02.005"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature16527"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500905"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.03.019"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201509-1751OC"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00035.2012"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.3791\/59496"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.06.021"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau9072"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abe3218"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102832"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00174.2012"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1605957113"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf1648"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00066.2008"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.06.014"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911934107"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.03.005"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00071"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72094"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901314RR"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402251111"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.3109\/09537101003615394"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302187"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-019-0134-8"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.08.016"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.02.089"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2022087118"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.12.033"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.03.004"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2006.00500.x"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00345.x"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20285"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009124"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.4163"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M009449"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.D089516"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103562200"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407057200"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2820"}],"container-title":["Science Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciimmunol.abj0474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T08:15:56Z","timestamp":1705392956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.abj0474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,24]]},"references-count":78,"journal-issue":{"issue":"66","published-print":{"date-parts":[[2021,12,24]]}},"alternative-id":["10.1126\/sciimmunol.abj0474"],"URL":"https:\/\/doi.org\/10.1126\/sciimmunol.abj0474","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.09.26.461888","asserted-by":"object"}]},"ISSN":["2470-9468"],"issn-type":[{"value":"2470-9468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,24]]},"article-number":"eabj0474"}}